Provided is a process for producing an isocoumarin-3-yl-acetic acid derivative, characterized by reacting a homophthalic acid derivative represented by a formula:
1
(wherein R
c
, R
2
and R are mainly protecting groups) with a malonic acid derivating represented by a formula:
2
(wherein R is an organic group including a lower alkyl group; R
3
is a protecting group for a carboxyl group; and X is a halogen atom or a —OM group (wherein M is alkaline metal or alkaline earth metal)). According to the above process, various isocoumarin-3-yl-acetic acid derivatives can efficiently be provided.
本发明提供了一种生产异
香豆素-3-基
乙酸衍
生物的工艺,其特征在于将由式
1
(其中 R
c
, R
2
和 R 主要是保护基团)与
丙二酸衍
生物的结合,
丙二酸衍
生物的代表式为
2
(其中 R 为有机基团,包括低级烷基;R
3
是羧基的保护基团;X 是卤素原子或 -OM 基团(其中 M 是碱
金属或碱土
金属))。根据上述工艺,可以有效地提供各种异
香豆素-3-基
乙酸衍
生物。