1-phenyl-5-[6-(trifluoromethylsulfonyl)-1H-benzimidazol-2-yl]pyridin-2-one | 1359858-06-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-phenyl-5-[6-(trifluoromethylsulfonyl)-1H-benzimidazol-2-yl]pyridin-2-one
• CAS: 1359858-06-2
• 化学式: C₁₉H₁₂F₃N₃O₃S
• 分子量: 419.384
• InChiKey: TWDJYRDXTHJMHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  91.5
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  6-氯烟酸 在 盐酸 、 tris-(dibenzylideneacetone)dipalladium(0) 、 copper(l) iodide 、 N,N-二甲基甘氨酸 、 palladium on activated charcoal 、 氢气 、 sodium hydride 、 potassium carbonate 、 三乙胺 、 N,N-二异丙基乙胺 、 间氯过氧苯甲酸 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 、 二氯甲烷 、 2,4-滴二甲胺盐 、 N,N-二甲基甲酰胺 为溶剂， 生成 1-phenyl-5-[6-(trifluoromethylsulfonyl)-1H-benzimidazol-2-yl]pyridin-2-one
  参考文献：
  名称：

  Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles

  摘要：

  Optimization of our HTS hit 1, mainly focused on modification at the C-2 position of the benzimidazole core, is described. Elimination of the flexible and metabolically labile -S-CH2- part and utilization of less lipophilic pyridone substructure led to identification of novel NPY Y5 receptor antagonists 6, which have low to sub-nanomolar Y5 receptor binding affinity with improved CYP450 inhibition profiles, good solubilities and high metabolic stabilities. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.07.020

文献信息

• Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles
  作者：Yuusuke Tamura、Naoki Omori、Naoki Kouyama、Yuji Nishiura、Kyouhei Hayashi、Kana Watanabe、Yukari Tanaka、Takeshi Chiba、Hideo Yukioka、Hiroki Sato、Takayuki Okuno

  DOI：10.1016/j.bmcl.2012.07.020

  日期：2012.9

  Optimization of our HTS hit 1, mainly focused on modification at the C-2 position of the benzimidazole core, is described. Elimination of the flexible and metabolically labile -S-CH2- part and utilization of less lipophilic pyridone substructure led to identification of novel NPY Y5 receptor antagonists 6, which have low to sub-nanomolar Y5 receptor binding affinity with improved CYP450 inhibition profiles, good solubilities and high metabolic stabilities. (c) 2012 Elsevier Ltd. All rights reserved.