2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxyphenyl]-N-(1-ethylpyrazol-4-yl)acetamide | 1374784-87-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxyphenyl]-N-(1-ethylpyrazol-4-yl)acetamide
• CAS: 1374784-87-8
• 化学式: C₂₄H₂₅N₅O₅
• 分子量: 463.493
• InChiKey: CZSOWVHBIBQBJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-[4-(6,7-dimethoxyquinazolin-4-yloxy)-2-methoxyphenyl]acetic acid 、 4-氨基-1-乙基吡唑 在 2-羟基吡啶-N-氧化物 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 14.0h， 以38%的产率得到2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxyphenyl]-N-(1-ethylpyrazol-4-yl)acetamide
  参考文献：
  名称：

  Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases

  摘要：

  A new series of quinoline ether inhibitors, which potently and selectively inhibit PDGFR tyrosine kinases, is described in this Letter. Compounds 23 and 33 are selective, low nanomolar inhibitors of PDGFR alpha and beta, display good pharmacokinetics in rat and dog and are active in vivo at low doses when given orally twice daily. Further evaluation of these compounds is warranted. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.03.074

文献信息

• Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases
  作者：Patrick A. Plé、Frédéric Jung、Sue Ashton、Laurent Hennequin、Romuald Laine、Christine Lambert-van der Brempt、Rémy Morgentin、Georges Pasquet、Sian Taylor

  DOI：10.1016/j.bmcl.2012.03.074

  日期：2012.5

  A new series of quinoline ether inhibitors, which potently and selectively inhibit PDGFR tyrosine kinases, is described in this Letter. Compounds 23 and 33 are selective, low nanomolar inhibitors of PDGFR alpha and beta, display good pharmacokinetics in rat and dog and are active in vivo at low doses when given orally twice daily. Further evaluation of these compounds is warranted. (C) 2012 Elsevier Ltd. All rights reserved.