(S)-(+)-7-(1H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydroquinoline | 945213-69-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (S)-(+)-7-(1H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydroquinoline
• 英文别名: (7R)-7-(1H-imidazol-5-ylmethyl)-5,6,7,8-tetrahydroquinoline
• CAS: 945213-69-4
• 化学式: C₁₃H₁₅N₃
• 分子量: 213.282
• InChiKey: SIDBSMXMBWXFQV-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PHARMACEUTICAL COMPOSITIONS COMPRISING 7-(1H-IMIDAZOL-4-YLMETHYL)-5,6,7,8-TETRAHYDRO-QUINOLINE
  申请人：ALLERGAN, INC.

  公开号：EP3184110A1

  公开（公告）日：2017-06-28

  The present invention relates to a method for treating ocular diseases in a patient in need thereof which comprises of administering a therapeutically effective amount of a pharmaceutical composition comprising a therapeutically effective amount of 7-(1H-Imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline, or its individual enantiomers or the tautomers thereof, or a pharmaceutically acceptable salt thereof.

  本发明涉及一种治疗有需要的患者眼部疾病的方法，该方法包括施用治疗有效量的药物组合物，该药物组合物包含治疗有效量的7-(1H-咪唑-4-基甲基)-5,6,7,8-四氢喹啉或其单个对映体或其同系物或其药学上可接受的盐。
• Pharmaceutical compositions comprising 7-(1H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline for treating skin diseases and conditions
  申请人：Allergan, Inc.

  公开号：US10201535B2

  公开（公告）日：2019-02-12

  The present invention relates to a method for treating skin diseases and skin conditions in a patient in need thereof which comprises of administering a therapeutically effective amount of a pharmaceutical composition comprising a therapeutically effective amount of 7-(1H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline, or its individual enantiomers or the tautomers thereof, or a pharmaceutically acceptable salt thereof.

  本发明涉及一种治疗有需要的患者的皮肤病和皮肤状况的方法，该方法包括施用治疗有效量的药物组合物，该药物组合物包含治疗有效量的7-(1H-咪唑-4-基甲基)-5,6,7,8-四氢喹啉或其单个对映体或其同系物或其药学上可接受的盐。
• PHARMACEUTICAL COMPOSITIONS COMPRISING 7-(1H-IMIDAZOL-4-YLMETHYL)-5,6,7,8-TETRAHYDRO-QUINOLINE FOR TREATING SKIN DISEASES AND CONDITIONS
  申请人：ALLERGAN, INC.

  公开号：EP2776034A1

  公开（公告）日：2014-09-17
• OPHTHALMIC COMPOSITIONS COMPRISING POLYVINYL CAPROLACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMERS (SOLUPLUS)
  申请人：ALLERGAN, INC.

  公开号：EP2790673B1

  公开（公告）日：2017-07-05
• PHARMACEUTICAL COMPOSITIONS COMPRISING (S)-(+)-7-(1H-IMIDAZOL-4-YLMETHYL)-5,6,7,8-TETRAHYDRO-QUINOLINE FOR TREATING SKIN DISEASES AND CONDITIONS
  申请人：ALLERGAN, INC.

  公开号：EP2776034B1

  公开（公告）日：2017-03-22