1-[2-(1-Pyrrolidinyl)phenyl]-1-propanone | 107075-96-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[2-(1-Pyrrolidinyl)phenyl]-1-propanone
• 英文别名: 1-(2-pyrrolidin-1-ylphenyl)propan-1-one
• CAS: 107075-96-7
• 化学式: C₁₃H₁₇NO
• 分子量: 203.28
• InChiKey: GDSXRNMXPOFBGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS
  申请人：Berger Richard

  公开号：US20090253705A1

  公开（公告）日：2009-10-08

  The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.

  本发明提供了式(I)的化合物，其药物组成物以及使用该化合物在治疗或预防由β3-肾上腺素受体激活介导的疾病的方法。
• IMMUNOASSAY FOR PYRROLIDINOPHENONES
  申请人：RANDOX LABORATORIES LIMITED

  公开号：US20160097783A1

  公开（公告）日：2016-04-07

  The current invention provides an improved immunoassay for the detection and determination of pyrrolidinophenone based designer drugs in hair and biological fluids (urine, blood, and oral fluid). The generic immunoassay is underpinned by novel, sub-family-specific antibodies, which display surprising sensitivity. The invention further describes substrates comprising an antibody that is specific to compounds of the pyrrolidinophenone family. Also described are the novel immunogens from which the antibodies are derived and kits incorporating the antibodies of the current invention.

  该发明提供了一种改进的免疫测定方法，用于检测和测定基于哌哆利啶酮类设计药物在头发和生物液体（尿液、血液和口腔液）中的含量。通用的免疫测定方法基于新颖的、亚家族特异性抗体，显示出惊人的灵敏度。该发明进一步描述了包含特异于哌哆利啶酮类化合物的抗体的底物。还描述了从中获得抗体的新颖免疫原以及包含本发明抗体的试剂盒。
• Derivatives of 3-pyrrolidinopropiophenone and a process for preparation thereof
  申请人：Hokuriku Pharmaceutical Co.,Ltd

  公开号：EP0150235A1

  公开（公告）日：1985-08-07

  Derivatives of 3-pyrrolidinopropiophenone of the formula (I) wherein R is an ethyl-, propyl-, isopropyl-, butyl-, isobutylgroup or a cycloalkyl-group having 5 to 7 carbon atoms, and the pharmaceutically acceptable acid addition salts thereof, exhibit a potent activity on muscle relaxation. Furtheron a process for the preparation of these compounds is disclosed.

  式（I）中 R 为乙基、丙基、异丙基、丁基、异丁基或具有 5 至 7 个碳原子的环烷基的 3-吡咯烷基苯丙酮的衍生物及其药学上可接受的酸加成盐具有强效的肌肉松弛活性。 此外，还公开了制备这些化合物的工艺。
• 6,5-BICYCLIC OCTAHYDROPYRROLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS
  申请人：Kim Ronald M.

  公开号：US20170320874A1

  公开（公告）日：2017-11-09

  The present invention is directed to 6,5-bicyclic octahydropyrrolopyridine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
• US8399480B2
  申请人：——

  公开号：US8399480B2

  公开（公告）日：2013-03-19