((R)-4-tert-Butoxycarbonylamino-5-hydroxy-6-{(R)-3-phenyl-1-[4-(quinolin-3-ylcarbamoyl)-oxazol-2-yl]-propylamino}-hexyl)-carbamic acid tert-butyl ester | 233690-80-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ((R)-4-tert-Butoxycarbonylamino-5-hydroxy-6-{(R)-3-phenyl-1-[4-(quinolin-3-ylcarbamoyl)-oxazol-2-yl]-propylamino}-hexyl)-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[(3R)-2-hydroxy-6-[(2-methylpropan-2-yl)oxycarbonylamino]-1-[[(1R)-3-phenyl-1-[4-(quinolin-3-ylcarbamoyl)-1,3-oxazol-2-yl]propyl]amino]hexan-3-yl]carbamate
• CAS: 233690-80-7
• 化学式: C₃₈H₅₀N₆O₇
• 分子量: 702.851
• InChiKey: LBYWSXMOHXWNBC-VOKSZNSDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  51
• 可旋转键数：
  19
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  177
• 氢给体数：
  5
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  三氟乙酸 、 ((R)-4-tert-Butoxycarbonylamino-5-hydroxy-6-{(R)-3-phenyl-1-[4-(quinolin-3-ylcarbamoyl)-oxazol-2-yl]-propylamino}-hexyl)-carbamic acid tert-butyl ester 以 二氯甲烷 为溶剂， 生成 2-[(R)-1-((R)-3,6-Diamino-2-hydroxy-hexylamino)-3-phenyl-propyl]-oxazole-4-carboxylic acid quinolin-3-ylamide; compound with trifluoro-acetic acid
  参考文献：
  名称：

  Peptidomimetics of Efflux Pump Inhibitors Potentiate the Activity of Levofloxacin in Pseudomonas aeruginosa

  摘要：

  Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas aeruginosa. A number of the new analogues were as active or more active than the lead. demonstrating that a peptide backbone is not essential for activity. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00006-9
• 作为产物：
  描述：

  3-氨基喹啉 在 potassium carbonate 、 三乙胺 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 ((R)-4-tert-Butoxycarbonylamino-5-hydroxy-6-{(R)-3-phenyl-1-[4-(quinolin-3-ylcarbamoyl)-oxazol-2-yl]-propylamino}-hexyl)-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Peptidomimetics of Efflux Pump Inhibitors Potentiate the Activity of Levofloxacin in Pseudomonas aeruginosa

  摘要：

  Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas aeruginosa. A number of the new analogues were as active or more active than the lead. demonstrating that a peptide backbone is not essential for activity. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00006-9

文献信息

• US6436980B1
  申请人：——

  公开号：US6436980B1

  公开（公告）日：2002-08-20
• Peptidomimetics of Efflux Pump Inhibitors Potentiate the Activity of Levofloxacin in Pseudomonas aeruginosa
  作者：Thomas E. Renau、Roger Léger、Rose Yen、Miles W. She、Eric M. Flamme、Joan Sangalang、Carla L. Gannon、Suzanne Chamberland、Olga Lomovskaya、Ving J. Lee

  DOI：10.1016/s0960-894x(02)00006-9

  日期：2002.3

  Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas aeruginosa. A number of the new analogues were as active or more active than the lead. demonstrating that a peptide backbone is not essential for activity. (C) 2002 Elsevier Science Ltd. All rights reserved.