2-(2,4-dimethoxyphenyl)-6-(4-methoxyphenylazo)imidazo<1,2-a>pyrimidine | 102362-11-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(2,4-dimethoxyphenyl)-6-(4-methoxyphenylazo)imidazo<1,2-a>pyrimidine
• 英文别名: [2-(2,4-Dimethoxyphenyl)imidazo[1,2-a]pyrimidin-6-yl]-(4-methoxyphenyl)diazene
• CAS: 102362-11-8
• 化学式: C₂₁H₁₉N₅O₃
• 分子量: 389.414
• InChiKey: ATNTXIBHKOLLSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  82.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-(4-methoxyphenylazo)malondialdehyde 在 sodium ethanolate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.5h， 生成 2-(2,4-dimethoxyphenyl)-6-(4-methoxyphenylazo)imidazo<1,2-a>pyrimidine
  参考文献：
  名称：

  Inotropic 2-arylimidazol[1,2-a]pyrimidines

  摘要：

  A series of 2-arylimidazo[1,2-a]pyrimidines has been prepared and evaluated for inotropic activity. Three of these heterocycles. ether 19, sulphide 21 and mesylate 24 displayed more potent inotropic effects in vitro than isomazole. The in vivo inotropic potencies of 4'-mesylate 24 and 4'-carboxamido analogue 23 were similar to those of isomazole and sulmazole respectively. The effects of some 'A' and 'C' ring substituents on the inotropic activities of the imidazo[1,2-a]pyrimidines were different from those on the imidazopyridines. Nevertheless the inotropic potencies of several imidazo[1.2-a]pyrimidines were closer to those of their 1H-imidazo[4,5-b]pyridine isomers than to those of the corresponding isomazole analogues. Structure-activity relationships are discussed in detail.

  DOI：

  10.1016/0223-5234(92)90004-k

文献信息

• Inotropic 2-arylimidazol[1,2-a]pyrimidines
  作者：P Barraclough、JW Black、D Cambridge、E Capon、MR Cox、D Firmin、VP Gerskowitch、H Giles、RC Glen、AP Hill、RAD Hull、R Iyer、D Kettle、WR King、MS Nobbs、P Randall、P Skone、S Smith、SJ Vine、CJ Wharton、MV Whiting

  DOI：10.1016/0223-5234(92)90004-k

  日期：1992.4

  A series of 2-arylimidazo[1,2-a]pyrimidines has been prepared and evaluated for inotropic activity. Three of these heterocycles. ether 19, sulphide 21 and mesylate 24 displayed more potent inotropic effects in vitro than isomazole. The in vivo inotropic potencies of 4'-mesylate 24 and 4'-carboxamido analogue 23 were similar to those of isomazole and sulmazole respectively. The effects of some 'A' and 'C' ring substituents on the inotropic activities of the imidazo[1,2-a]pyrimidines were different from those on the imidazopyridines. Nevertheless the inotropic potencies of several imidazo[1.2-a]pyrimidines were closer to those of their 1H-imidazo[4,5-b]pyridine isomers than to those of the corresponding isomazole analogues. Structure-activity relationships are discussed in detail.