ethyl (4S,5S)-4-[tert-butyl(dimethyl)silyl]oxy-5-(dibenzylamino)-6-methylhept-2-ynoate | 908129-90-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl (4S,5S)-4-[tert-butyl(dimethyl)silyl]oxy-5-(dibenzylamino)-6-methylhept-2-ynoate
• CAS: 908129-90-8
• 化学式: C₃₀H₄₃NO₃Si
• 分子量: 493.762
• InChiKey: DRAHUYBNPIMMDJ-YTMVLYRLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.67
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl (4S,5S)-4-[tert-butyl(dimethyl)silyl]oxy-5-(dibenzylamino)-6-methylhept-2-ynoate 在 palladium dihydroxide 四丁基氟化铵 、 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 tert-butyl ((S)-2-methyl-1-((R)-5-oxotetrahydrofuran-2-yl)propyl)carbamate
  参考文献：
  名称：

  Diastereoselective syntheses of 2-amino propargyl alcohols. Chiral building blocks for enantiopure amino γ-lactones and 5-hydroxy-piperidinone derivatives

  摘要：

  alpha-Dibenzylamino aldehydes, derived from the corresponding natural alpha-amino acids, react with metal acetylides to yield anti-amino propargyl alcohols in good yield and diastereomeric excess. syn Amino alcohols are prepared from the. anti diastereo-isomers and all of them are elaborated in few steps to enantiopure amino lactones and hydroxy-piperidin-2-ones. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.05.131
• 作为产物：
  描述：

  (3S,4S)-4-(dibenzylamino)-5-methylhex-1-yn-3-ol 在 咪唑 、 正丁基锂 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成 ethyl (4S,5S)-4-[tert-butyl(dimethyl)silyl]oxy-5-(dibenzylamino)-6-methylhept-2-ynoate
  参考文献：
  名称：

  Diastereoselective syntheses of 2-amino propargyl alcohols. Chiral building blocks for enantiopure amino γ-lactones and 5-hydroxy-piperidinone derivatives

  摘要：

  alpha-Dibenzylamino aldehydes, derived from the corresponding natural alpha-amino acids, react with metal acetylides to yield anti-amino propargyl alcohols in good yield and diastereomeric excess. syn Amino alcohols are prepared from the. anti diastereo-isomers and all of them are elaborated in few steps to enantiopure amino lactones and hydroxy-piperidin-2-ones. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.05.131