4-((3-(3-carboxypropyl)benzo[d]thiazole-2(3H)-ylidene)methyl)-1-methylquinolinium bromide | 1056651-38-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-((3-(3-carboxypropyl)benzo[d]thiazole-2(3H)-ylidene)methyl)-1-methylquinolinium bromide
• 英文别名: 4-((3-(3-Carboxypropyl)benzo[d]thiazole-2(3h)-ylidene)methyl)-1-methylquinoliniumbromide；4-[2-[(1-methylquinolin-1-ium-4-yl)methylidene]-1,3-benzothiazol-3-yl]butanoic acid;bromide
• CAS: 1056651-38-7
• 化学式: Br*C₂₂H₂₁N₂O₂S
• 分子量: 457.391
• InChiKey: RJEDXZVQGQMHDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.44
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  69.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-((3-(3-carboxypentyl)benzo[d]thiazole-2(3H)-ylidene)methyl)-1-methylquinolinium bromide 、 3-(4-Carboxypentyl)-2-methylbenzothiazolium bromide 、 2-甲基-1,3-苯并噻唑-3-鎓溴化物 、 以which was obtained with a yield of 26%的产率得到4-((3-(3-carboxypropyl)benzo[d]thiazole-2(3H)-ylidene)methyl)-1-methylquinolinium bromide
  参考文献：
  名称：

  Primer, primer set, and nucleic acid amplification method and mutation detection method using the same

  摘要：

  本发明提供了一种引物，可以有效地检测核酸的双螺旋结构。该引物是一种带标记的核酸，至少含有以下公式（16）所表示的一种结构，其中B是具有核碱基骨架的原子基团，E是具有脱氧核糖骨架、核糖骨架或从它们中任意一个衍生的结构的原子基团，或者是具有肽结构或肽酰基结构的原子基团，而Z11和Z12是各自表现出荧光的原子基团，它们相同或不同。

  公开号：

  US20080227104A1

文献信息

• Compound having structure derived from mononucleoside or mononucleotide, nucleic acid, labeling substance, and method and kit for detection of nucleic acid
  申请人：Okamoto Akimitsu

  公开号：US08383792B2

  公开（公告）日：2013-02-26

  The present invention provides, for example, a labeling substance that allows the double helix structure of a nucleic acid to be detected effectively. The present invention provides a compound having a structure derived from mononucleoside or mononucleotide, with the structure being represented by the following formula (1), (1b), or (1c), a tautomer or stereoisomer thereof, or a salt thereof. In the above formulae, B is an atomic group having a nucleobase skeleton, E is an atomic group having a deoxyribose skeleton, a ribose skeleton, or a structure derived from either one of them, or an atomic group having a peptide structure or a peptoid structure, and Z11 and Z12 each are a hydrogen atom, a protecting group, or an atomic group that exhibits fluorescence and may be identical to or different from each other.

  本发明提供了一种标记物质，例如，允许有效检测核酸的双螺旋结构。本发明提供了一种化合物，其结构源自单核苷酸或单核苷酸，该结构由以下公式（1），（1b）或（1c）表示，或其互变异构体或立体异构体，或其盐。在上述公式中，B是具有核碱基骨架的原子基团，E是具有脱氧核糖骨架，核糖骨架或源自其中任何一种的结构的原子基团，或具有肽结构或肽骨架的原子基团，Z11和Z12分别是氢原子，保护基或表现出荧光并且可以相同或不同的原子基团。
• METHOD FOR ANALYZING TARGET NUCLEIC ACID, KIT, AND ANALYZER
  申请人：KABUSHIKI KAISHA DNAFORM

  公开号：US20150152496A1

  公开（公告）日：2015-06-04

  The present invention is to provide a method for analyzing a target nucleic acid, by which the target nucleic acid can be analyzed rapidly and easily. In order to achieve the above object, the present invention provides a method for analyzing a target nucleic acid in a sample, including the step of: analyzing the target nucleic acid in the sample by bringing the sample into contact with a label and with a primer or probe that can hybridize to the target nucleic acid. The primer or probe is immobilized on a solid phase. The label does not emit light when the primer or probe does not hybridize to the target nucleic acid, whereas the label emits light when the primer or probe has hybridized to the target nucleic acid. The analysis is carried out by detecting the light emitted from the label.

  本发明提供了一种分析目标核酸的方法，可以快速简便地分析目标核酸。为了达到上述目的，本发明提供了一种在样品中分析目标核酸的方法，包括以下步骤：将样品与一个标记和一个可以与目标核酸杂交的引物或探针接触，从而分析样品中的目标核酸。引物或探针被固定在固相上。当引物或探针未与目标核酸杂交时，标记不会发出光，而当引物或探针与目标核酸杂交时，标记会发出光。通过检测标记发出的光来进行分析。
• NUCLEIC ACID PROBE, METHOD FOR DESIGNING NUCLEIC ACID PROBE, AND METHOD FOR DETECTING TARGET SEQUENCE
  申请人：KABUSHIKI KAISHA DNAFORM

  公开号：US20150203902A1

  公开（公告）日：2015-07-23

  The present invention provides a nucleic acid probe that can achieve high detection sensitivity and high specificity in mutation detection, mismatch detection, etc. by the PCR method, a method for designing such a nucleic acid probe, and a method for detecting a target sequence. The nucleic acid probe includes a nucleic acid molecule, and the nucleic acid molecule includes a plurality of fluorescent dye moieties that exhibit an excitonic effect. At least two of the fluorescent dye moieties that exhibit an excitonic effect are bound to the same base or two adjacent bases in the nucleic acid molecule with each fluorescent dye moiety being bound via a linker (a linking atom or a linking atomic group). The extension-side end of the nucleic acid molecule is chemically modified, thereby preventing an extension reaction of the nucleic acid molecule.

  本发明提供了一种核酸探针，该探针可以通过PCR方法在突变检测、错配检测等方面实现高检测灵敏度和高特异性，以及设计这种核酸探针的方法和检测目标序列的方法。该核酸探针包括一个核酸分子，该核酸分子包括多个表现出激子效应的荧光染料基团。至少两个表现出激子效应的荧光染料基团与核酸分子中的同一碱基或相邻的两个碱基结合，每个荧光染料基团通过连接物（连接原子或连接原子团）结合。核酸分子的延伸侧端经过化学修饰，从而防止核酸分子的扩增反应。
• Method for analyzing target nucleic acid, kit, and analyzer
  申请人：KABUSHIKI KAISHA DNAFORM

  公开号：US10066264B2

  公开（公告）日：2018-09-04

  The present invention is to provide a method for analyzing a target nucleic acid, by which the target nucleic acid can be analyzed rapidly and easily. In order to achieve the above object, the present invention provides a method for analyzing a target nucleic acid in a sample, including the step of: analyzing the target nucleic acid in the sample by bringing the sample into contact with a label and with a primer or probe that can hybridize to the target nucleic acid. The primer or probe is immobilized on a solid phase. The label does not emit light when the primer or probe does not hybridize to the target nucleic acid, whereas the label emits light when the primer or probe has hybridized to the target nucleic acid. The analysis is carried out by detecting the light emitted from the label.

  本发明旨在提供一种分析靶核酸的方法，通过该方法可以快速简便地分析靶核酸。为了实现上述目的，本发明提供了一种分析样品中靶核酸的方法，包括以下步骤：通过使样品与标签和能与靶核酸杂交的引物或探针接触，分析样品中的靶核酸。引物或探针固定在固相上。当引物或探针未与目标核酸杂交时，标签不发光，而当引物或探针与目标核酸杂交时，标签发光。通过检测标签发出的光进行分析。
• COMPOUND HAVING STRUCTURE DERIVED FROM MONONUCLEOSIDE OR MONONUCLEOTIDE, NUCLEIC ACID, LABELING SUBSTANCE, AND METHOD AND KIT FOR DETECTION OF NUCLEIC ACID
  申请人：Riken

  公开号：EP2130835B1

  公开（公告）日：2012-05-23