2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-β-galactopyranosyl)-α-D-mannopyranosyl diphenyl phosphate | 222040-94-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-β-galactopyranosyl)-α-D-mannopyranosyl diphenyl phosphate
• CAS: 222040-94-0
• 化学式: C₃₈H₄₅O₂₁P
• 分子量: 868.736
• InChiKey: XLCQPRCSFBNNHL-DOBRKLPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.89
• 重原子数：
  60.0
• 可旋转键数：
  17.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  256.55
• 氢给体数：
  0.0
• 氢受体数：
  21.0

反应信息

• 作为反应物：
  描述：

  2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-β-galactopyranosyl)-α-D-mannopyranosyl diphenyl phosphate 在 platinum(IV) oxide 氢气 作用下， 反应 16.0h， 生成 Acetic acid (2R,3S,4S,5R,6R)-3-acetoxy-6-acetoxymethyl-2-phosphonooxy-5-((2S,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yl ester
  参考文献：
  名称：

  Synthesis of the phosphodisaccharide repeat of antigenic lipophosphoglycan of Leishmania donovani parasite

  摘要：

  Synthesis of the immunologically important and structurally unusual phosphodisaccharide repeat unit (Galp1,4 beta-Manp-1 alpha-phosphate) of the lipophosphoglycan cell surface GPI molecule of the protozoan parasite Leishmania donovani has been carried out using lactose as the starting material. The synthesis provides a short and stereoselective route for the preparation of this phosphosaccharide in a preparative scale. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00231-2
• 作为产物：
  描述：

  1,2,3,6-tetra-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-α-D-mannopyranose 在 正丁基锂 、 二甲胺 作用下， 以 乙腈 为溶剂， 生成 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-β-galactopyranosyl)-α-D-mannopyranosyl diphenyl phosphate
  参考文献：
  名称：

  Synthesis of the phosphodisaccharide repeat of antigenic lipophosphoglycan of Leishmania donovani parasite

  摘要：

  Synthesis of the immunologically important and structurally unusual phosphodisaccharide repeat unit (Galp1,4 beta-Manp-1 alpha-phosphate) of the lipophosphoglycan cell surface GPI molecule of the protozoan parasite Leishmania donovani has been carried out using lactose as the starting material. The synthesis provides a short and stereoselective route for the preparation of this phosphosaccharide in a preparative scale. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00231-2