2,3-dihydro-1'-[3-(2-oxo-3,4-dihydro-1(2H)-quinolinyl)propyl]spiro[1H-indene-1,4'-piperidine] | 480999-52-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,3-dihydro-1'-[3-(2-oxo-3,4-dihydro-1(2H)-quinolinyl)propyl]spiro[1H-indene-1,4'-piperidine]
• 英文别名: 1-(3-Spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)-3,4-dihydroquinolin-2-one
• CAS: 480999-52-8
• 化学式: C₂₅H₃₀N₂O
• 分子量: 374.526
• InChiKey: UPKKKHVXTGCLBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Spiropiperidine compounds as ligands for ORL-1 receptor
  申请人：Pfizer Inc.

  公开号：US20030078278A1

  公开（公告）日：2003-04-24

  A compound of the formula: 1 or a salt, prodrug or solvate thereof, wherein R 1 and R 2 groups are all hydrogen; A is a benzofuzed azahetero ring; W 1 —W 2 is CH 2 —CH 2 ; X 1 —X 2 is CH 2 —CH 2 ; and Z is methylene or carbonyl; or the like, is a ligand for ORL1-receptor and are useful for treating or preventing pain, a CNS disorder or the like in mammalian subjects.

  该公式的化合物：1或其盐、前药或溶剂，其中R1和R2基团均为氢；A为苯并噻杂环；W1-W2为CH2- ；X1-X2为 - ；Z为亚甲基或羰基；或类似物，是ORL1受体的配体，可用于治疗或预防哺乳动物主体中的疼痛、中枢神经系统紊乱或类似疾病。
• Spiropiperidine compounds as ligands for ORL-1receptor
  申请人：Pfizer Inc.

  公开号：US20030078279A1

  公开（公告）日：2003-04-24

  A compound of the formula: 1 or a salt, prodrug or solvate thereof, wherein R 1 and R 2 groups are all hydrogen; A is a benzofuzed azahetero ring; W 1 -W 2 is CH 2 -CH 2 ; X 1 -X 2 is CH 2 -CH 2 ; and Z is methylene or carbonyl; or the like, is a ligand for ORL1-receptor and are useful for treating or preventing pain, a CNS disorder or the like in mammalian subjects.

  式中的化合物： 1 或其盐、原药或溶液，其中 R 1 和 R 2 基团均为氢；A 为苯并偶氮杂环；W 1 -W 2 是 CH 2 -CH 2 ; X 1 -X 2 是 CH 2 -CH 2 和 Z 是亚甲基或羰基；或类似物，是 ORL1 受体的配体，可用于治疗或预防哺乳动物的疼痛、中枢神经系统疾病或类似疾病。
• SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR
  申请人：PFIZER INC.

  公开号：EP1399432A1

  公开（公告）日：2004-03-24
• Spiropoperidine compounds as ligands for orl-1 receptor
  申请人：Ando Koji

  公开号：US20050038060A1

  公开（公告）日：2005-02-17

  A compound of the formula (I) or a salt, prodrug or solvate thereof, wherein R 1 and R 2 groups are all hydrogen; A is a benzofuzed azahetero ring; W 1 —W 2 is CH 2 —CH 2 ; X 1 —X 1 is CH 2 —CH 2 ; and Z is methylene or carbonyl; or the like, is a ligand for ORL1-receptor and are useful for treating or preventing pain, a CNS disorder or the like in mammalian subjects.
• [EN] SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR<br/>[FR] COMPOSES DE SPIROPIPERIDINE UTILISES COMME LIGANDS POUR LE RECEPTEUR ORL-1
  申请人：PFIZER PHARMA

  公开号：WO2003000677A1

  公开（公告）日：2003-01-03

  A compound of the formula (I) or a salt, prodrug or solvate thereof, wherein R?1 and R2¿ groups are all hydrogen; A is a benzofuzed azahetero ring; W1-W2 is CH¿2?-CH2; X?1-X1¿ is CH¿2?-CH2; and Z is methylene or carbonyl; or the like, is a ligand for ORL1-receptor and are useful for treating or preventing pain, a CNS disorder or the like in mammalian subjects.