1,4-dihydro-4-oxo-7-(trifluoromethylthio)quinoline-3-carboxylic acid | 1256932-82-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,4-dihydro-4-oxo-7-(trifluoromethylthio)quinoline-3-carboxylic acid
• 英文别名: 4-oxo-7-(trifluoromethylsulfanyl)-1H-quinoline-3-carboxylic acid
• CAS: 1256932-82-7
• 化学式: C₁₁H₆F₃NO₃S
• 分子量: 289.235
• InChiKey: BYHADRTWVWAAJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1,4-dihydro-4-oxo-7-(trifluoromethylthio)quinoline-3-carboxylic acid 以 二苯醚 为溶剂， 反应 0.5h， 以68%的产率得到7-(trifluoromethylthio)quinoline-4-one
  参考文献：
  名称：

  Synthesis and anti-prion activity evaluation of aminoquinoline analogues

  摘要：

  Transmissible spongiform encephalopathies form a group of neurodegenerative diseases that affect humans and other mammals. They occur when the native prion protein is converted into an infectious isoform, the scrapie PrP, which aggregates, leading to neurodegeneration. Although several compounds were evaluated for their ability to inhibit this conversion, there is no effective therapy for such diseases. Previous studies have shown that antimalarial compounds, such as quinolines, possess anti-scrapie activity. Here, we report the synthesis and evaluate the effect of aminoquinoline derivatives on the aggregation of a prion peptide. Our results show that 4-amino-7-chloroquinoline and N-(7-chloro-4-quinolinyl)-1,2-ethanediamine inhibit the aggregation significantly. Therefore, such aminoquinolines might be considered as candidates for the further development of therapeutics to prevent the development of prion diseases. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.07.054
• 作为产物：
  描述：

  ethyl 1,4-dihydro-4-oxo-7-(trifluoromethylthio)quinoline-3-carboxylate 在 水 、 sodium hydroxide 作用下， 反应 2.0h， 以70%的产率得到1,4-dihydro-4-oxo-7-(trifluoromethylthio)quinoline-3-carboxylic acid
  参考文献：
  名称：

  Synthesis and anti-prion activity evaluation of aminoquinoline analogues

  摘要：

  Transmissible spongiform encephalopathies form a group of neurodegenerative diseases that affect humans and other mammals. They occur when the native prion protein is converted into an infectious isoform, the scrapie PrP, which aggregates, leading to neurodegeneration. Although several compounds were evaluated for their ability to inhibit this conversion, there is no effective therapy for such diseases. Previous studies have shown that antimalarial compounds, such as quinolines, possess anti-scrapie activity. Here, we report the synthesis and evaluate the effect of aminoquinoline derivatives on the aggregation of a prion peptide. Our results show that 4-amino-7-chloroquinoline and N-(7-chloro-4-quinolinyl)-1,2-ethanediamine inhibit the aggregation significantly. Therefore, such aminoquinolines might be considered as candidates for the further development of therapeutics to prevent the development of prion diseases. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.07.054

文献信息

• Synthesis and anti-prion activity evaluation of aminoquinoline analogues
  作者：Bruno Macedo、Catherine H. Kaschula、Roger Hunter、Juliana A.P. Chaves、Johannes D. van der Merwe、Jerson L. Silva、Timothy J. Egan、Yraima Cordeiro

  DOI：10.1016/j.ejmech.2010.07.054

  日期：2010.11

  Transmissible spongiform encephalopathies form a group of neurodegenerative diseases that affect humans and other mammals. They occur when the native prion protein is converted into an infectious isoform, the scrapie PrP, which aggregates, leading to neurodegeneration. Although several compounds were evaluated for their ability to inhibit this conversion, there is no effective therapy for such diseases. Previous studies have shown that antimalarial compounds, such as quinolines, possess anti-scrapie activity. Here, we report the synthesis and evaluate the effect of aminoquinoline derivatives on the aggregation of a prion peptide. Our results show that 4-amino-7-chloroquinoline and N-(7-chloro-4-quinolinyl)-1,2-ethanediamine inhibit the aggregation significantly. Therefore, such aminoquinolines might be considered as candidates for the further development of therapeutics to prevent the development of prion diseases. (C) 2010 Elsevier Masson SAS. All rights reserved.