p-methoxyphenyl 2,3-di-O-benzoyl-β-D-glucopyranosyl-(1→4)-2,3-di-O-benzyl-β-L-fucopyranosyl-(1→4)-2,3-di-O-benzoyl-6-O-benzyl-β-D-glucopyranosyl-(1→3)-4-O-acetyl-2,6-di-O-benzyl-β-D-galactopyranoside | 1616968-85-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: p-methoxyphenyl 2,3-di-O-benzoyl-β-D-glucopyranosyl-(1→4)-2,3-di-O-benzyl-β-L-fucopyranosyl-(1→4)-2,3-di-O-benzoyl-6-O-benzyl-β-D-glucopyranosyl-(1→3)-4-O-acetyl-2,6-di-O-benzyl-β-D-galactopyranoside
• CAS: 1616968-85-4
• 化学式: C₉₆H₉₆O₂₆
• 分子量: 1665.8
• InChiKey: NVPMGBXZLHHNGM-BFXWTZMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.53
• 重原子数：
  122.0
• 可旋转键数：
  36.0
• 环数：
  14.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  301.18
• 氢给体数：
  2.0
• 氢受体数：
  26.0

反应信息

• 作为反应物：
  描述：

  p-methoxyphenyl 2,3-di-O-benzoyl-β-D-glucopyranosyl-(1→4)-2,3-di-O-benzyl-β-L-fucopyranosyl-(1→4)-2,3-di-O-benzoyl-6-O-benzyl-β-D-glucopyranosyl-(1→3)-4-O-acetyl-2,6-di-O-benzyl-β-D-galactopyranoside 在 sodium hypochlorite 、 2,2,6,6-四甲基哌啶氧化物 、 四丁基溴化铵 、 碳酸氢钠 、 potassium bromide 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Chemical synthesis of a tetrasaccharide related to the exocellular polysaccharide from Rhodococcus sp. RHA1

  摘要：

  Chemical synthesis of the tetrasaccharide related to the exocellular polysaccharide from Rhodococcus sp. RHA1 is reported. The stereoselective glycosylations were achieved by activation of the thioglycoside donors using N-iodosuccinimide in the presence of La(OTf)(3) varying temperature per the need of 1,2-cis or 1,2-trans glycosylations. The target tetrasaccharide is reported in the form of its p-methoxyphenyl glycoside that can be cleaved selectively from the per-O-acetylated derivative allowing further glycoconjugate formation using trichloroacetimidate chemistry. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2014.05.018
• 作为产物：
  描述：

  p-methoxyphenyl 4,6-O-benzylidene-2,3-di-O-benzoyl-β-D-glucopyranosyl-(1→4)-2,3-di-O-benzyl-β-L-fucopyranosyl-(1→4)-2,3-di-O-benzoyl-6-O-benzyl-β-D-glucopyranosyl-(1→3)-4-O-acetyl-2,6-di-O-benzyl-β-D-galactopyranoside 在 溶剂黄146 作用下， 以 水 为溶剂， 反应 2.0h， 以91%的产率得到p-methoxyphenyl 2,3-di-O-benzoyl-β-D-glucopyranosyl-(1→4)-2,3-di-O-benzyl-β-L-fucopyranosyl-(1→4)-2,3-di-O-benzoyl-6-O-benzyl-β-D-glucopyranosyl-(1→3)-4-O-acetyl-2,6-di-O-benzyl-β-D-galactopyranoside
  参考文献：
  名称：

  Chemical synthesis of a tetrasaccharide related to the exocellular polysaccharide from Rhodococcus sp. RHA1

  摘要：

  Chemical synthesis of the tetrasaccharide related to the exocellular polysaccharide from Rhodococcus sp. RHA1 is reported. The stereoselective glycosylations were achieved by activation of the thioglycoside donors using N-iodosuccinimide in the presence of La(OTf)(3) varying temperature per the need of 1,2-cis or 1,2-trans glycosylations. The target tetrasaccharide is reported in the form of its p-methoxyphenyl glycoside that can be cleaved selectively from the per-O-acetylated derivative allowing further glycoconjugate formation using trichloroacetimidate chemistry. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2014.05.018