tert-butyl-[(E,4S)-1-(2-methoxyethoxymethoxy)-7-methyl-9-(1-phenyltetrazol-5-yl)sulfonylnon-7-en-2-yn-4-yl]oxy-diphenylsilane | 1240411-71-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: tert-butyl-[(E,4S)-1-(2-methoxyethoxymethoxy)-7-methyl-9-(1-phenyltetrazol-5-yl)sulfonylnon-7-en-2-yn-4-yl]oxy-diphenylsilane
• CAS: 1240411-71-5
• 化学式: C₃₇H₄₆N₄O₆SSi
• 分子量: 702.947
• InChiKey: WQIKESLDLYWYFN-TWQHIOKGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.75
• 重原子数：
  49
• 可旋转键数：
  18
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  123
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  (4S)-4-methyl-8-phenylmethoxyoctanal 、 tert-butyl-[(E,4S)-1-(2-methoxyethoxymethoxy)-7-methyl-9-(1-phenyltetrazol-5-yl)sulfonylnon-7-en-2-yn-4-yl]oxy-diphenylsilane 在 双(三甲基硅烷基)氨基钾 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Progress towards the total synthesis of 2,3-dihydroxytrinervitanes

  摘要：

  Intramolecular Diels-Alder approach to construct the fused AB ring of trinervitane has been demonstrated efficiently. The key intermediate for the Diels-Alder cyclization has been achieved following highly stereoselective Julia-Kocienski olefination, Sharp less epoxidation and Evan's asymmetric alkylation as the key reactions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.065
• 作为产物：
  描述：

  (S,E)-5-((6-((tert-butyldiphenylsilyl)oxy)-9-((2-methoxyethoxy)methoxy)-3-methylnon-2-en-7-yn-1-yl)thio)-1-phenyl-1H-tetrazole 在 ammonium molybdate 、 双氧水 作用下， 以 乙醇 为溶剂， 以70%的产率得到tert-butyl-[(E,4S)-1-(2-methoxyethoxymethoxy)-7-methyl-9-(1-phenyltetrazol-5-yl)sulfonylnon-7-en-2-yn-4-yl]oxy-diphenylsilane
  参考文献：
  名称：

  Progress towards the total synthesis of 2,3-dihydroxytrinervitanes

  摘要：

  Intramolecular Diels-Alder approach to construct the fused AB ring of trinervitane has been demonstrated efficiently. The key intermediate for the Diels-Alder cyclization has been achieved following highly stereoselective Julia-Kocienski olefination, Sharp less epoxidation and Evan's asymmetric alkylation as the key reactions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.065