(R)-2-(4-methylpiperidin-1-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline | 1234793-09-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (R)-2-(4-methylpiperidin-1-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline
• 英文别名: 2-(4-methylpiperidin-1-yl)-6-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]quinoline
• CAS: 1234793-09-9
• 化学式: C₂₂H₃₁N₃
• 分子量: 337.508
• InChiKey: YAOWUNOWVQEGOW-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  19.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲基哌啶 、 反应 16.0h， 以68%的产率得到(R)-2-(4-methylpiperidin-1-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline
  参考文献：
  名称：

  In vitro studies on a class of quinoline containing histamine H3 antagonists

  摘要：

  A series of quinoline containing histamine H-3 antagonists is reported herein. These analogs were synthesized via the Friedlander quinoline synthesis between an aminoaldehyde intermediate and a methyl ketone allowing for a wide diversity of substituents at the 2-position of the quinoline ring. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.045

文献信息

• In vitro studies on a class of quinoline containing histamine H3 antagonists
  作者：Huaqing Liu、Robert J. Altenbach、Gilbert J. Diaz、Arlene M. Manelli、Ruth L. Martin、Thomas R. Miller、Timothy A. Esbenshade、Jorge D. Brioni、Marlon D. Cowart

  DOI：10.1016/j.bmcl.2010.04.045

  日期：2010.6

  A series of quinoline containing histamine H-3 antagonists is reported herein. These analogs were synthesized via the Friedlander quinoline synthesis between an aminoaldehyde intermediate and a methyl ketone allowing for a wide diversity of substituents at the 2-position of the quinoline ring. (C) 2010 Elsevier Ltd. All rights reserved.