6-Aminocycloheptindol | 36146-65-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-Aminocycloheptindol
• 英文别名: cyclohepta[b]indol-6-ylamine
• CAS: 36146-65-3
• 化学式: C₁₃H₁₀N₂
• 分子量: 194.236
• InChiKey: KXTMWIVOOGNSDG-UHFFFAOYSA-N

文献信息

• COMPOUNDS FOR THE REDUCTION OF THE DELETERIOUS ACTIVITY OF EXTENDED NUCLEOTIDE REPEAT CONTAINING GENES
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：EP3641758A1

  公开（公告）日：2020-04-29
• Compounds for The Reduction of The Deleterious Activity of Extended Nucleotide Repeat Containing Genes
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20200147069A1

  公开（公告）日：2020-05-14

  Aspects of the present disclosure include methods of reducing the deleterious impact of a target gene in a cell, such as the deleterious activity of a mutant extended nucleotide repeat (NR) containing target gene in a cell by contacting the cell with an effective amount of a tetrahydrocarbazolamine compound. The deleterious activity (e.g., toxicity and/or dis-functionality of products encoded thereby) of a mutant extended NR containing target gene may be reduced, e.g., by reducing (and in some instances differentially, including selectively, reducing) the production or activity of toxic expression products (e.g., RNA or protein) encoded by the target gene. Kits and compositions for practicing the subject methods are also provided.
• [EN] COMPOUNDS FOR THE REDUCTION OF THE DELETERIOUS ACTIVITY OF EXTENDED NUCLEOTIDE REPEAT CONTAINING GENES<br/>[FR] COMPOSÉS POUR LA RÉDUCTION DE L'ACTIVITÉ DÉLÉTÈRE DE GÈNES CONTENANT UNE RÉPÉTITION DE NUCLÉOTIDES ÉTENDUE
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2018236910A1

  公开（公告）日：2018-12-27

  Aspects of the present disclosure include methods of reducing the deleterious impact of a target gene in a cell, such as the deleterious activity of a mutant extended nucleotide repeat (NR) containing target gene in a cell by contacting the cell with an effective amount of a tetrahydrocarbazolamine compound. The deleterious activity (e.g., toxicity and/or dis-functionality of products encoded thereby) of a mutant extended NR containing target gene may be reduced, e.g., by reducing (and in some instances differentially, including selectively, reducing) the production or activity of toxic expression products (e.g., RNA or protein) encoded by the target gene. Kits and compositions for practicing the subject methods are also provided.