3-amino-N-[(8-methyl-2-{methyl[(1-methylpiperidin-4-yl)methyl]amino}quinolin-3-yl)methyl]pyrazine-2-carboxamide | 1365615-40-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-amino-N-[(8-methyl-2-{methyl[(1-methylpiperidin-4-yl)methyl]amino}quinolin-3-yl)methyl]pyrazine-2-carboxamide
• 英文别名: US9670212, 31 3-amino-N-[(8-methyl-2-{methyl[(1-methylpiperidin-4-yl)methyl]amino}quinolin-3-yl)methyl]pyrazine-2-carboxamide；3-amino-N-[[8-methyl-2-[methyl-[(1-methylpiperidin-4-yl)methyl]amino]quinolin-3-yl]methyl]pyrazine-2-carboxamide
• CAS: 1365615-40-2
• 化学式: C₂₄H₃₁N₇O
• 分子量: 433.556
• InChiKey: PBMLLDPKTHEYFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE<br/>[FR] INHIBITEUR DE PI3K-DELTA ET PROCÉDÉS D'UTILISATION ET DE FABRICATION CORRESPONDANTS
  申请人：EXELIXIS INC

  公开号：WO2012037226A1

  公开（公告）日：2012-03-22

  The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

  这项发明涉及到式I的化合物及其药用可接受的盐或溶剂合物，以及制备和使用这些化合物的方法。
• [EN] INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE<br/>[FR] INHIBITEURS DE PI3K-? ET LEURS PROCÉDÉS D'UTILISATION ET FABRICATION
  申请人：EXELIXIS INC

  公开号：WO2012037204A1

  公开（公告）日：2012-03-22

  The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

  该发明涉及公式I的化合物：以及这些化合物的药用盐或溶剂合物，以及制备和使用这些化合物的方法。
• Inhibitors of PI3K-Delta and Methods of Their Use and Manufacture
  申请人：Leahy James William

  公开号：US20140045825A1

  公开（公告）日：2014-02-13

  The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

  该发明涉及式I的化合物：以及其药学上可接受的盐或溶剂，以及制备和使用该化合物的方法。
• Inhibitors of PI3K-delta and methods of their use and manufacture
  申请人：Exelixis, Inc.

  公开号：US10053470B2

  公开（公告）日：2018-08-21

  The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof as well as methods of making and using the compounds.

  本发明涉及式 I：化合物及其药学上可接受的盐或溶液，以及制造和使用这些化合物的方法。
• INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE
  申请人：Exelixis, Inc.

  公开号：EP2616442A1

  公开（公告）日：2013-07-24