1-(1-adamantyl)-2-methoxymethoxyethanol | 162005-41-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(1-adamantyl)-2-methoxymethoxyethanol
• CAS: 162005-41-6
• 化学式: C₁₄H₂₄O₃
• 分子量: 240.343
• InChiKey: ARFKVARGUWTLGU-JEFIIJIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.18
• 重原子数：
  17.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.69
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  1-(1-adamantyl)-2-methoxymethoxyethanol 在 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以54%的产率得到
  参考文献：
  名称：

  Preparation of homochiral crown ether containing (S)-1-(1-adamantyl)ethane-1,2-diol as a chiral subunit and its enantioselective complexation with an organic ammonium cation

  摘要：

  Homochiral 1-(1-adamantyl)ethane-1,2-diol(5) was prepared and its absolute configuration was determined to be (S)-(+)-5 by enzymatic and H-1 n.m.r. spectroscopic methods. Using (S)-(+)-5 as a chiral subunit, the homochiral crown ether (+)-18 was synthesized and its enantioselectivity in complexation of methionine methyl ester perchlorate was also examined by the H-1 n.m.r. spectroscopic method.

  DOI：

  10.1016/0957-4166(94)80125-8
• 作为产物：
  描述：

  1-(1-金刚烷基)乙烯 在 吡啶 、 四氧化锇 、 水 、 N-甲基吗啉氧化物 、 N,N-二异丙基乙胺 作用下， 以 氯仿 、 叔丁醇 为溶剂， 反应 57.0h， 生成 1-(1-adamantyl)-2-methoxymethoxyethanol
  参考文献：
  名称：

  Preparation of homochiral crown ether containing (S)-1-(1-adamantyl)ethane-1,2-diol as a chiral subunit and its enantioselective complexation with an organic ammonium cation

  摘要：

  Homochiral 1-(1-adamantyl)ethane-1,2-diol(5) was prepared and its absolute configuration was determined to be (S)-(+)-5 by enzymatic and H-1 n.m.r. spectroscopic methods. Using (S)-(+)-5 as a chiral subunit, the homochiral crown ether (+)-18 was synthesized and its enantioselectivity in complexation of methionine methyl ester perchlorate was also examined by the H-1 n.m.r. spectroscopic method.

  DOI：

  10.1016/0957-4166(94)80125-8