tert-butyl (1S,4S,7S,9S)-9-bromo-4-[[tert-butyl(dimethyl)silyl]oxymethyl]-4,7-dihydroxy-5-methyl-3,6-dioxo-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-triene-16-carboxylate | 1219135-50-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: tert-butyl (1S,4S,7S,9S)-9-bromo-4-[[tert-butyl(dimethyl)silyl]oxymethyl]-4,7-dihydroxy-5-methyl-3,6-dioxo-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-triene-16-carboxylate
• CAS: 1219135-50-8
• 化学式: C₂₆H₃₈BrN₃O₇Si
• 分子量: 612.593
• InChiKey: BAFJTHAJRWBHNC-JTQLPTLWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.46
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  tert-butyl (1S,4S,7S,9S)-9-bromo-4-[[tert-butyl(dimethyl)silyl]oxymethyl]-4,7-dihydroxy-5-methyl-3,6-dioxo-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-triene-16-carboxylate 在 偶氮二甲氧基异庚腈 、 三正丁基氢锡 作用下， 以 苯 为溶剂， 以100%的产率得到
  参考文献：
  名称：

  Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: Reducing cytotoxicity by structural simplification

  摘要：

  Chaetocin (1), a structurally complex epidithiodiketopiperazine (ETP) alkaloid produced by Chaetomium minutum, is a potent inhibitor of protein lysine methyltransferase G9a, which plays important roles in many biological processes. Here we present our synthetic investigations to identify a simple prototype G9a inhibitor structure based on structure-activity relationship (SAR) studies on chaetocin derivatives. The simple derivative PS-ETP-1 (14) was found to be a potent G9a inhibitor with greatly reduced cytotoxicity. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.11.087
• 作为产物：
  描述：

  methyl N-((benzyloxy)carbonyl)-O-(tert-butyldimethylsilyl)-N-methyl-D-seryl-D-tryptophanate 在 4-二甲氨基吡啶 、 N-溴代丁二酰亚胺(NBS) 、 偶氮二甲氧基异庚腈 、 palladium 10% on activated carbon 、 氨 、 水 、 氢气 作用下， 以 甲醇 、 四氯化碳 、 乙醇 、 水 、 乙腈 为溶剂， 反应 87.0h， 生成 、 tert-butyl (1S,4S,7S,9S)-9-bromo-4-[[tert-butyl(dimethyl)silyl]oxymethyl]-4,7-dihydroxy-5-methyl-3,6-dioxo-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-triene-16-carboxylate
  参考文献：
  名称：

  Total syntheses of chaetocin and ent-chaetocin

  摘要：

  The first total synthesis of chaetocin (1), a potent histone methyltransferase inhibitor, is described in detail. Key reactions were radical bromination for alpha-oxidation of the diketopiperazine ring, and reductive radical coupling for construction of the dimeric core structure. Stereoselective construction of the disulfide bridges was achieved via substitution reaction with H2S. The total synthesis of 1 was accomplished in nine steps starting from known D-amino acid derivatives. Total synthesis of non-natural ent-chaetocin (ent-1) was also achieved via the established synthetic route, starting from.-amino acid derivatives. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.05.081

文献信息

• Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: Reducing cytotoxicity by structural simplification
  作者：Shinya Fujishiro、Kosuke Dodo、Eriko Iwasa、Yuou Teng、Yoshihiro Sohtome、Yoshitaka Hamashima、Akihiro Ito、Minoru Yoshida、Mikiko Sodeoka

  DOI：10.1016/j.bmcl.2012.11.087

  日期：2013.2

  Chaetocin (1), a structurally complex epidithiodiketopiperazine (ETP) alkaloid produced by Chaetomium minutum, is a potent inhibitor of protein lysine methyltransferase G9a, which plays important roles in many biological processes. Here we present our synthetic investigations to identify a simple prototype G9a inhibitor structure based on structure-activity relationship (SAR) studies on chaetocin derivatives. The simple derivative PS-ETP-1 (14) was found to be a potent G9a inhibitor with greatly reduced cytotoxicity. (c) 2012 Elsevier Ltd. All rights reserved.
• Total syntheses of chaetocin and ent-chaetocin
  作者：Eriko Iwasa、Yoshitaka Hamashima、Shinya Fujishiro、Daisuke Hashizume、Mikiko Sodeoka

  DOI：10.1016/j.tet.2011.05.081

  日期：2011.9

  The first total synthesis of chaetocin (1), a potent histone methyltransferase inhibitor, is described in detail. Key reactions were radical bromination for alpha-oxidation of the diketopiperazine ring, and reductive radical coupling for construction of the dimeric core structure. Stereoselective construction of the disulfide bridges was achieved via substitution reaction with H2S. The total synthesis of 1 was accomplished in nine steps starting from known D-amino acid derivatives. Total synthesis of non-natural ent-chaetocin (ent-1) was also achieved via the established synthetic route, starting from.-amino acid derivatives. (C) 2011 Elsevier Ltd. All rights reserved.