5-Chloro-4-(4-ethylphenoxy)-2-(4-methylphenyl)-3-pyridazinone | 1415356-39-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Chloro-4-(4-ethylphenoxy)-2-(4-methylphenyl)-3-pyridazinone
• 英文别名: 5-chloro-4-(4-ethylphenoxy)-2-(4-methylphenyl)pyridazin-3-one
• CAS: 1415356-39-6
• 化学式: C₁₉H₁₇ClN₂O₂
• 分子量: 340.809
• InChiKey: FPOISEYHNOEDPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对甲基苯肼 在 sodium hydride 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 6.0h， 生成 5-Chloro-4-(4-ethylphenoxy)-2-(4-methylphenyl)-3-pyridazinone
  参考文献：
  名称：

  Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)

  摘要：

  Novel smallmolecule antagonists ofNPBWR1 (GPR7) are herein reported. A high-throughput screening (HTS) of the Molecular Libraries-Small Molecule Repository library identified 5-chloro-4-(4-methoxyphenoxy)-2-(p-tolyl)pyridazin-3(2H)-one as a NPBWR1 hit antagonist with micromolar activity. Design, synthesis and structure-activity relationships study of the HTS-derived hit led to the identification of 5-chloro-2-(3,5-dimethylphenyl)-4-(4-methoxyphenoxy) pyridazin-3(2H)-one lead molecule with sub-micromolar antagonist activity at the target receptor and high selectivity against a panel of therapeutically relevant off-target proteins. This lead molecule may provide a pharmacological tool to clarify the molecular basis of the in vivo physiological function and therapeutic utility of NPBWR1 in diverse disease areas including inflammatory pain and eating disorders. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.09.074