1-[4-(Dimethylamino)-1-naphthyl]-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]thiourea | 1227092-05-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-[4-(Dimethylamino)-1-naphthyl]-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]thiourea
• 英文别名: 1-[4-(dimethylamino)naphthalen-1-yl]-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]thiourea
• CAS: 1227092-05-8
• 化学式: C₂₃H₂₇N₅S
• 分子量: 405.567
• InChiKey: OLVHHBHEMMFRNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  84.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS USEFUL AS HIV BLOCKERS<br/>[FR] COMPOSÉS UTILES EN TANT QU'INHIBITEURS DE VIH
  申请人：SCHERING CORP

  公开号：WO2010057101A2

  公开（公告）日：2010-05-20

  The present invention relates to a compound having the general Formula (I): wherein the variables are as defined in the specification. The present invention further relates to pharmaceutical compositions comprising these compounds and to their use in therapy, in particular for the treatment or prevention of chemokine-mediated disorders such as HIV infection.