fludarabine | 19768-92-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: fludarabine
• 英文别名: 9-(β-D-Xylofuranosyl)-2-fluor-adenin；(2R,3R,4R,5R)-2-(6-Amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol；(2R,3R,4R,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• CAS: 19768-92-4
• 化学式: C₁₀H₁₂FN₅O₄
• 分子量: 285.235
• InChiKey: HBUBKKRHXORPQB-FTWQFJAYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  140
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• [EN] [<18>F]-FURANOSYLPURINE DERIVATIVES AND USES THEREOF<br/>[FR] DERIVES DE [<18>F]-FURANOSYLPURINE ET LEURS UTILISATIONS
  申请人：UNIV SOUTHERN CALIFORNIA

  公开号：WO2004096138A2

  公开（公告）日：2004-11-11

  2'-Deoxy-2'- [18F] -labeled and 3'-deoxy-3'- [18F] -labeled purine nucleoside analogs such as [18F]-FAA and [18F]­FXA have been found to have desirable properties for use as imaging agents. The analogs are particularly useful for in vivo imaging of biological material including organ tissues (e.g., heart, liver, brain and kidneys) and tumors. Methods for the preparation of the [18F]-FAA and [18F]-FXA are also provided.