3-溴-5-氯戊烷-2-酮 | 58371-99-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-溴-5-氯戊烷-2-酮
• 英文名称: 3-bromo-5-chloropentan-2-one
• 英文别名: 3-bromo-5-chloro-2-pentanone；3-Brom-5-chlorpentanon-2；2-Pentanone, 3-bromo-5-chloro-
• CAS: 58371-99-6
• 化学式: C₅H₈BrClO
• 分子量: 199.475
• InChiKey: UHMBBBZVSNBZMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-溴-5-氯戊烷-2-酮 在 苄基三乙基氯化铵 、 sodium hydroxide 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以15.9 g的产率得到1-(1-溴环丙基)乙酮
  参考文献：
  名称：

  一种1-卤代-1-乙酰基环丙烷的合成方法

  摘要：

  本发明公开了一种1‑卤代‑1‑乙酰基环丙烷的合成方法：以3,5‑二卤代‑2‑戊酮为原料，在碱的作用下，以苄基三乙基氯化铵为相转移催化剂，制备1‑卤代‑1‑乙酰基环丙烷化合物。本发明公开的方法操作简单、反应迅速、产率高，解决了快速高效合成1‑卤代‑1‑乙酰基环丙烷化合物的难题，本发明主要用于含环丙烷结构单元的有机分子的合成。

  公开号：

  CN107759457A
• 作为产物：
  描述：

  5-氯-2-戊酮 、 甲醇 生成 3-溴-5-氯戊烷-2-酮
  参考文献：
  名称：

  SEMENOVA N. A.; KATVALYAN G. T.; MISTRYUKOV E. A., TETRAHEDRON LETT, , 1976 NO 6, 445-446

  摘要：

  DOI：

文献信息

• Benzhydrylpiperozinyl thiazole derivatives and pharmaceutical
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04411900A1

  公开（公告）日：1983-10-25

  Benzhydrylpiperazinyl Thiazole compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, amino, or mono- or di- substituted amino, in which the substituent is selected from lower alkyl, acyl and di(lower)alkylaminomethylene, R.sup.2 is hydrogen, halogen, lower alkyl or aryl, R.sup.3 is ar(lower)alkyl optionally substituted by halogen, A is lower alkylene optionally interrupted by a sulfur atom, and Y is C.sub.1 -C.sub.3 alkylene, having antiallergic activity.

  Benzhydrylpiperazinyl噻唑化合物的化学式为##STR1##其中R.sup.1为氢，氨基，或者单取代或双取代氨基，取代基选自较低的烷基，酰基和二(较低)烷基氨基甲烯，R.sup.2为氢，卤素，较低的烷基或芳基，R.sup.3为可选择地被卤素取代的芳基(较低)烷基，A为可选择地由硫原子中断的较低烷基，Y为C.sub.1 -C.sub.3烷基，具有抗过敏活性。
• Methods of Inhibiting Metastasis from Cancer
  申请人：Salvino Joseph M.

  公开号：US20120141471A1

  公开（公告）日：2012-06-07

  The present invention includes compositions that are useful in preventing or treating metastasis in a subject diagnosed with cancer. The present invention also includes methods of preventing or treating metastasis in a subject diagnosed with cancer, wherein the method comprises administering to the subject in need thereof an effective amount of a pharmaceutical formulation comprising at least one pharmaceutically acceptable carrier and at least one CX 3 CR1 or fractalkine antagonist.

  本发明涉及一种用于预防或治疗被诊断为癌症的患者中的转移的组合物。本发明还包括一种用于预防或治疗被诊断为癌症的患者中的转移的方法，其中该方法包括向需要该药物的患者投与至少一种药用制剂，该制剂包括至少一种药用载体和至少一种CX3CR1或fractalkine拮抗剂的有效量。
• Compounds Useful for Inhibiting Metastasis from Cancer and Methods Using Same
  申请人：Drexel University College of Medicine Philadelphia Health & Education Corporation d/b/a

  公开号：US20130156761A1

  公开（公告）日：2013-06-20

  The present invention includes compositions that are useful in preventing or treating metastasis in a subject diagnosed with cancer. The present invention also includes methods of preventing or treating metastasis in a subject diagnosed with cancer, wherein the method comprises administering to the subject in need thereof an effective amount of a pharmaceutical formulation comprising at least one pharmaceutically acceptable carrier and at least one CX 3 CR1 or fractalkine antagonist.

  本发明涉及一种对已被诊断患有癌症的受试者预防或治疗转移的有用组合物。本发明还涉及一种预防或治疗已被诊断患有癌症的受试者的转移的方法，其中该方法包括向需要该药物的受试者施用至少一种药物制剂，该药物制剂包括至少一种药用载体和至少一种CX3CR1或fractalkine拮抗剂的有效量。
• Thiazole derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0032058A1

  公开（公告）日：1981-07-15

  The thiazole derivatives have the general formula:- wherein R1 is hydrogen, amino, or mono-or di-substituted amino, in which the substituent is selected from lower alkyl, acyl and di (lower) alkylaminomethylene, R2 is hydrogen, halogen, lower alkyl or aryl, R3 is ar(lower)alkyl optionally substituted by halogen, A is lower alkylene optionally interrupted by a sulfur atom, and Y is C1-C3 alkylene, and their pharmaceutically - acceptable salts, are useful as antiallergic agents.

  噻唑衍生物的通式如下 其中 R1 是氢、氨基或单或二取代氨基，其中取代基选自低级烷基、酰基和二（低级）烷基氨基亚甲基、 R2 是氢、卤素、低级烷基或芳基、 R3 是可选被卤素取代的 ar（低级）烷基、 A 是可选被硫原子打断的低级亚烷基，以及 Y 是 C1-C3 亚烷基，以及它们的药学上可接受的 盐可用作抗过敏剂。
• Imidazole compound and process for preparing the same
  申请人：ISHIHARA SANGYO KAISHA, Ltd.

  公开号：EP0365030A1

  公开（公告）日：1990-04-25

  An imidazole compound is disclosed, which is represented by formula (I): wherein: X represents a -COOT group, in which T represents a hydrogen atom, an alkyl group, a benzyl group, or a phenyl group; or a -CONH₂ group, Y represents a hydrogen atom, a chlorine atom, or a bromine atom, Z represents an alkyl group containing from 2 to 6 carbon atoms, which may be substituted with one or more halogen atoms; or a phenyl group which may be substituted with one or more halogen atoms or alkyl groups, and Q represeents a hydrogen atom; an -SO₂R¹group, in which R¹ represents an alkyl group, a dialkylamino group, or a phenyl group which may be substituted with one or more alkyl groups; or a -CH(R²) (R³) group, in which R² represents a hydrogen atom, a methyl group, or an alkoxy group, and R³ represents an alkoxy group, an -OCH₂CH₂Si(CH₃)₃ group, or a phenyl group which may be substituted with one or more alkyl groups or alkoxy groups, provided that when Y and Q each represents a hydrogen atom and Z represents a phenyl group, X represents a group other than a -COOH group, a -COO-phenyl group, and a -CONH₂ group; and that when Y and Q each represents a hydrogen atom and Z represents an n-C₅H₁₁ group, X represents a group other than a -COOH group and a -COOC₂H₅ group. Processes for preparing imidazole compounds are also disclosed. The imidazole compounds are useful as an intermediate for production of biocides for controlling harmful organisms in the agricultural and horticultural areas, or medical and pharmaceutical fungicides.

  本发明公开了一种咪唑化合物，由式(I)表示： 其中 X代表-COOT基团，其中T代表氢原子、烷基、苄基或苯基；或代表-CONH₂基团、 Y 代表氢原子、氯原子或溴原子、 Z 代表含有 2 至 6 个碳原子的烷基，可被一个或多个卤素原子取代；或代表可被一个或多个卤素原子或烷基取代的苯基，以及 Q 代表氢原子；-SO₂R¹ 基团，其中 R¹ 代表烷基、二烷基氨基或可被一个或多个烷基取代的苯基；或-CH(R²) (R³)基团，其中 R² 代表氢原子、甲基或烷氧基，R³ 代表烷氧基、-OCH₂CH₂Si(CH₃)₃基团或可被一个或多个烷基或烷氧基取代的苯基、 条件是当 Y 和 Q 各代表一个氢原子且 Z 代表一个苯基时，X 代表一个除-COOH 基团、-COO-苯基基团和-CONH₂基团以外的基团；当 Y 和 Q 各代表一个氢原子且 Z 代表一个 n-C₅H₁₁ 基团时，X 代表一个除-COOH 基团和-COOC₂H₅基团以外的基团。 本发明还公开了制备咪唑化合物的工艺。 咪唑化合物可用作生产用于控制农业和园艺领域有害生物的杀菌剂或医用和药用杀菌剂的中间体。