2,2-dimethylpropionic acid-2-((R)-isopropylpiperidin-3-yl-carbamoyl)-4-(2-methoxyethoxy)quinolin-8-yl ester | 1443459-18-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,2-dimethylpropionic acid-2-((R)-isopropylpiperidin-3-yl-carbamoyl)-4-(2-methoxyethoxy)quinolin-8-yl ester
• 英文别名: [4-(2-methoxyethoxy)-2-[[(3R)-piperidin-3-yl]-propan-2-ylcarbamoyl]quinolin-8-yl] 2,2-dimethylpropanoate
• CAS: 1443459-18-4
• 化学式: C₂₆H₃₇N₃O₅
• 分子量: 471.597
• InChiKey: UAMXIIJKQHZBDP-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  90
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] QUINOLINE DERIVATIVES AS RENIN INHIBITORS<br/>[FR] DÉRIVÉS DE QUINOLÉINE UTILISÉS EN TANT QU'INHIBITEURS DE LA RÉNINE
  申请人：SUN PHARMA ADVANCED RES CO LTD

  公开号：WO2013088452A2

  公开（公告）日：2013-06-20

  A compound of formula (I), formula (I) or pharmaceutically acceptable salt thereof, as renin inhibitor, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of cardiovascular disorders related to hypertension, in warm-blooded animals. Further the present invention also provides a method for treatment of disorders like congestive heart failure, cardiac hypertrophy, cardiac fibrosis, coronary artery disease, vasculopathy, neuropathy, intraocular hypertension, glaucoma, diabetic nephropathy, abnormal vascular growth, hyperaldosteronism etc.