Carbamic acid, N-[8-(aminooxy)octyl]-, 1,1-dimethylethyl ester | 2011713-76-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Carbamic acid, N-[8-(aminooxy)octyl]-, 1,1-dimethylethyl ester
• 英文别名: tert-butyl N-(8-aminooxyoctyl)carbamate
• CAS: 2011713-76-9
• 化学式: C₁₃H₂₈N₂O₃
• 分子量: 260.377
• InChiKey: DAPBIQWDUNHKSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.74
• 重原子数：
  18.0
• 可旋转键数：
  9.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  73.58
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  Carbamic acid, N-[8-(aminooxy)octyl]-, 1,1-dimethylethyl ester 在 水 、 sodium hydroxide 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 25.5h， 生成
  参考文献：
  名称：

  Synthesis of fluorescent molecular probes based on cis-cinnamic acid and molecular imaging of lettuce roots

  摘要：

  We synthesized azo dye- and fluorescence-labeled cis-cinnamic acid analogues possessing inhibitory activity agaihst lettuce root growth and a trans-isomer without bioactivity as a control probe. The radicles incubated with the azo dye-labeled analogue were stained red, with their tips especially deeply dyed. The fluorescent images of the radicles incubated with each of these molecular probes depicted that the root cap was fluorescence-stained. However, images of the control radicles prepared by staining with the trans-isomer fluorescent probe did not show emission at the root cap. These contrasts suggest specific localization of the cis-cinnamate analogue at the columella cells. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2016.08.060
• 作为产物：
  描述：

  8-氨基-1-辛醇 在 咪唑 、 碘 、 sodium hydride 、 一水合肼 、 三苯基膦 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 28.25h， 生成 Carbamic acid, N-[8-(aminooxy)octyl]-, 1,1-dimethylethyl ester
  参考文献：
  名称：

  Synthesis of fluorescent molecular probes based on cis-cinnamic acid and molecular imaging of lettuce roots

  摘要：

  We synthesized azo dye- and fluorescence-labeled cis-cinnamic acid analogues possessing inhibitory activity agaihst lettuce root growth and a trans-isomer without bioactivity as a control probe. The radicles incubated with the azo dye-labeled analogue were stained red, with their tips especially deeply dyed. The fluorescent images of the radicles incubated with each of these molecular probes depicted that the root cap was fluorescence-stained. However, images of the control radicles prepared by staining with the trans-isomer fluorescent probe did not show emission at the root cap. These contrasts suggest specific localization of the cis-cinnamate analogue at the columella cells. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2016.08.060