Chinolin-5,8-disulfonsaeure | 5825-30-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Chinolin-5,8-disulfonsaeure
• 英文别名: quinoline-5,8-disulfonic acid
• CAS: 5825-30-9
• 化学式: C₉H₇NO₆S₂
• 分子量: 289.29
• InChiKey: QHFXNJOLPYEQAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  138
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Compounds for inhibiting diseases and preparing cells for transplantation
  申请人：Clark Anne

  公开号：US20070015737A1

  公开（公告）日：2007-01-18

  Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid depositions, e.g. in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. The methods of the invention involved administering to a subject a therapeutic compound which inhibits IAPP-associated amyloid deposits. Accordingly, the compositions and method of the invention are useful for inhibiting IAPP-associated amyloidosis in disorders in which such amyloid deposition occurs, such an diabetes. The invention also provides a process for the preparation of cells suitable for transplantation into a mammal, which cells are capable of forming fibrils, said process comprising contacting the cells with an inhibitor of fibril formation. In particular the process prepares cells for use in a method of treating diabetes. Also provided are a culture medium comprising the inhibitor and cells for transplantation.

  用于治疗淀粉样变性的方法和组合物。具体来说，提供了用于抑制、预防和治疗淀粉样沉积的方法和组合物，例如在胰岛中，其中淀粉样沉积是与胰岛淀粉样多肽（IAPP）相关的淀粉样沉积或沉积物。本发明的方法涉及向受试者施用一种抑制IAPP相关淀粉样沉积的治疗化合物。因此，本发明的组合物和方法对于抑制在发生此类淀粉样沉积的疾病中的IAPP相关淀粉样变性是有用的，比如糖尿病。本发明还提供了一种用于制备适合移植到哺乳动物体内的细胞的方法，这些细胞能够形成纤维，该方法包括将细胞与纤维形成抑制剂接触。具体而言，该方法为用于治疗糖尿病的方法准备细胞。还提供了一种包含该抑制剂和用于移植的细胞的培养基。