{5-[(1-Butyl-1,2,3,4-tetrahydro-6-quinolyl)methylidene]-4-oxo-2-thioxothiazolidin-3-yl}acetic acid | 313479-28-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: {5-[(1-Butyl-1,2,3,4-tetrahydro-6-quinolyl)methylidene]-4-oxo-2-thioxothiazolidin-3-yl}acetic acid
• 英文别名: 2-[(5Z)-5-[(1-butyl-3,4-dihydro-2H-quinolin-6-yl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid
• CAS: 313479-28-6
• 化学式: C₁₉H₂₂N₂O₃S₂
• 分子量: 390.527
• InChiKey: NLVGSZQGLUMESW-WJDWOHSUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Method of inhibiting amyloid protein aggregation and imaging amyloid deposits
  申请人：——

  公开号：US20040220235A1

  公开（公告）日：2004-11-04

  The present invention provides a method of treating Alzheimer's disease using a compound of Formula I 1 Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula I and a method of imaging amyloid deposits, as well as new compounds of Formula I.

  本发明提供了一种利用I1式化合物治疗阿尔茨海默病的方法。还提供了一种利用I式化合物抑制淀粉样蛋白聚集的方法，以及一种成像淀粉样沉积物的方法，以及新的I式化合物。
• RHODANINE DERIVATIVES FOR USE IN A METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1192143A1

  公开（公告）日：2002-04-03
• US6972287B1
  申请人：——

  公开号：US6972287B1

  公开（公告）日：2005-12-06
• [EN] RHODANINE DERIVATIVES FOR USE IN A METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS<br/>[FR] DERIVES DE RHODANINE UTILISES DANS UN PROCEDE D'INHIBITION DE L'AGREGATION DE PROTEINES AMYLOIDES ET DE FORMATION D'IMAGES DE DEPOTS AMYLOIDES
  申请人：WARNER LAMBERT CO

  公开号：WO2000076987A1

  公开（公告）日：2000-12-21

  The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula (I) and a method of imaging amyloid deposits using compounds of Formula (I).