(3R)-3-ethylcyclododecan-1-one | 471854-55-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3R)-3-ethylcyclododecan-1-one
• CAS: 471854-55-4
• 化学式: C₁₄H₂₆O
• 分子量: 210.36
• InChiKey: NDXMKCXFCOKTDU-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (E)-cyclododec-2-enone 、 diethylzinc 在 chiral binaphthol-based phosphoramidite copper(II) bis(trifluoromethanesulfonate) 作用下， 以 甲苯 为溶剂， 反应 5.0h， 生成 (3R)-3-ethylcyclododecan-1-one 、
  参考文献：
  名称：

  Copper-catalyzed conjugate addition on macrocyclic, cyclic, and acyclic enones with a chiral phosphoramidite ligand having a C2-symmetric amine moiety

  摘要：

  A binaphthol-based phosphoramidite ligand (4.2 mol%) having a C-2-symmetric chiral amine moiety was examined for enantioselective 1,4-additions of dialkylzinc reagents to various macrocyclic, cyclic, and acyclic enones catalyzed by copper triflate-toluene complex (2 mol%) to afford high enantiomeric excess (up to >95% ee). (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(02)00206-9

文献信息

• Copper-catalyzed conjugate addition on macrocyclic, cyclic, and acyclic enones with a chiral phosphoramidite ligand having a C2-symmetric amine moiety
  作者：Yong Hyun Choi、Jun Young Choi、Hye Yon Yang、Yong Hae Kim

  DOI：10.1016/s0957-4166(02)00206-9

  日期：2002.5

  A binaphthol-based phosphoramidite ligand (4.2 mol%) having a C-2-symmetric chiral amine moiety was examined for enantioselective 1,4-additions of dialkylzinc reagents to various macrocyclic, cyclic, and acyclic enones catalyzed by copper triflate-toluene complex (2 mol%) to afford high enantiomeric excess (up to >95% ee). (C) 2002 Elsevier Science Ltd. All rights reserved.