(2R,3R,4R,5S,6R)-2-(acetoxymethyl)-6-(((1S,2S,2'S,3a'S,5R)-2-isopropyl-5,5'-dimethyl-4'-oxotetrahydro-2'H-spiro[cyclohexane-1,6'-imidazo[1,5-b]isoxazol]-2'-yl)methyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate | 341013-71-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子
• 英文名称: (2R,3R,4R,5S,6R)-2-(acetoxymethyl)-6-(((1S,2S,2'S,3a'S,5R)-2-isopropyl-5,5'-dimethyl-4'-oxotetrahydro-2'H-spiro[cyclohexane-1,6'-imidazo[1,5-b]isoxazol]-2'-yl)methyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
• CAS: 341013-71-6
• 化学式: C₃₀H₄₆N₂O₁₁
• 分子量: 610.702
• InChiKey: SIPMNJGFVRFSED-WWOOQTLTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.14
• 重原子数：
  43.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  147.21
• 氢给体数：
  0.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  (2R,3R,4R,5S,6R)-2-(acetoxymethyl)-6-(((1S,2S,2'S,3a'S,5R)-2-isopropyl-5,5'-dimethyl-4'-oxotetrahydro-2'H-spiro[cyclohexane-1,6'-imidazo[1,5-b]isoxazol]-2'-yl)methyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 在 盐酸 、 samarium diiodide 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 (2S,4S)-2-Amino-4-hydroxy-5-((2R,3S,4R,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-pentanoic acid
  参考文献：
  名称：

  Chiral Auxiliary Based Approach Toward the Synthesis of C-Glycosylated Amino Acids

  摘要：

  [GRAPHICS]In a chiral auxiliary based method C-glycosylated amino acids can be obtained by a 1,3-dipolar cycloaddition of a chiral glycine equivalent and C-1 allyl- or vinyl-derived carbohydrate building blocks as the key step. The products are formed regio- and diastereoselectively. Reductive cleavage of the N-O bond of the isoxazolidine and of the chiral auxiliary leads to C-glycosylated amino acids. The use of (-)-menthone to (+)-menthone as the auxiliary leads to the corresponding diastereomers.

  DOI：

  10.1021/ol015743j
• 作为产物：
  描述：

  (2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-1-propene 、 (-)-menthone nitrone 以 甲苯 为溶剂， 反应 36.0h， 以88%的产率得到(2R,3R,4R,5S,6R)-2-(acetoxymethyl)-6-(((1S,2S,2'S,3a'S,5R)-2-isopropyl-5,5'-dimethyl-4'-oxotetrahydro-2'H-spiro[cyclohexane-1,6'-imidazo[1,5-b]isoxazol]-2'-yl)methyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
  参考文献：
  名称：

  Chiral Auxiliary Based Approach Toward the Synthesis of C-Glycosylated Amino Acids

  摘要：

  [GRAPHICS]In a chiral auxiliary based method C-glycosylated amino acids can be obtained by a 1,3-dipolar cycloaddition of a chiral glycine equivalent and C-1 allyl- or vinyl-derived carbohydrate building blocks as the key step. The products are formed regio- and diastereoselectively. Reductive cleavage of the N-O bond of the isoxazolidine and of the chiral auxiliary leads to C-glycosylated amino acids. The use of (-)-menthone to (+)-menthone as the auxiliary leads to the corresponding diastereomers.

  DOI：

  10.1021/ol015743j