(S,S)-2-amino-1-(5-(2-[4-(benzothiazol-2-yloxy)-phenoxy]-ethyl)-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-ethanone | 1146691-77-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S,S)-2-amino-1-(5-(2-[4-(benzothiazol-2-yloxy)-phenoxy]-ethyl)-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-ethanone
• 英文别名: 2-amino-1-[(1S,4S)-5-[2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]ethanone
• CAS: 1146691-77-1
• 化学式: C₂₂H₂₄N₄O₃S
• 分子量: 424.524
• InChiKey: CTOUWKVYLNIIAX-HOTGVXAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Aryl-substituted bridged or fused diamines as modulators of leukotriene A4 hydrolase
  申请人：Bacani Genesis M.

  公开号：US20090111794A1

  公开（公告）日：2009-04-30

  Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A 4 hydrolase (LTA 4 H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA 4 H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

  芳基取代的桥接或融合二胺化合物，含有它们的药物组合物，以及使用这些化合物和药物组合物进行白三烯A4水解酶（LTA4H）调节和治疗由LTA4H活性介导的疾病状态、疾病和疾病，如过敏、哮喘、自身免疫疾病、瘙痒、炎症性肠病、溃疡性结肠炎和心血管疾病，包括动脉粥样硬化和预防心肌梗死的方法。
• Aryl-substituted bridged or fused diamines as modulators of leukotriene A4 hydrolase
  申请人：Bacani Genesis M.

  公开号：US20110263639A1

  公开（公告）日：2011-10-27

  Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A 4 hydrolase (LTA 4 H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA 4 H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

  芳基取代的桥接或融合二胺化合物，包含它们的制药组合物，以及使用这些化合物和制药组合物进行白三烯A4水解酶（LTA4H或LTA4H）调节和用于治疗由LTA4H活性介导的疾病状态，障碍和疾病的方法，如过敏，哮喘，自身免疫疾病，瘙痒，炎症性肠病，溃疡性结肠炎，以及心血管疾病，包括动脉粥样硬化和预防心肌梗死。
• ARYL-SUBSTITUTED BRIDGED OR FUSED DIAMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE
  申请人：Janssen Pharmaceutica N.V.

  公开号：EP2217237A1

  公开（公告）日：2010-08-18
• US7935725B2
  申请人：——

  公开号：US7935725B2

  公开（公告）日：2011-05-03
• US8344008B2
  申请人：——

  公开号：US8344008B2

  公开（公告）日：2013-01-01