3-(6-Quinolinoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one | 189954-61-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(6-Quinolinoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one
• 英文别名: 5,5-Dimethyl-4-(4-methylsulfonylphenyl)-3-quinolin-6-yloxyfuran-2-one
• CAS: 189954-61-8
• 化学式: C₂₂H₁₉NO₅S
• 分子量: 409.463
• InChiKey: MGPCJDUYMCTDRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  90.9
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Tyrosine kinase inhibitors
  申请人：——

  公开号：US20030100567A1

  公开（公告）日：2003-05-29

  The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

  本发明涉及抑制、调节和/或调节酪氨酸激酶信号传导的化合物，包含这些化合物的组合物，以及使用它们治疗酪氨酸激酶依赖性疾病和情况的方法，例如在哺乳动物中的血管生成、癌症、肿瘤生长、动脉粥样硬化、年龄相关性黄斑变性、糖尿病性视网膜病变、炎症性疾病等。
• Method of treating cancer
  申请人：——

  公开号：US20020042375A1

  公开（公告）日：2002-04-11

  The present invention relates to methods of treating cancer using a combination of a compound which is a PSA conjugate and an NSAID compound, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound which is a PSA conjugate and an NSAID compound. The invention also relates to methods of preparing such compositions.

  本发明涉及使用一种PSA共轭物和一种NSAID化合物的组合治疗癌症的方法，该方法包括向所述哺乳动物施用至少两种治疗剂量，所述治疗剂量选自一组包括一种PSA共轭物和一种NSAID化合物，所述治疗剂量可以顺序给药或同时给药。该发明还涉及制备这种组合物的方法。
• [EN] TYROSINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE TYROSINE KINASE
  申请人：MERCK & CO INC

  公开号：WO2003011836A1

  公开（公告）日：2003-02-13

  The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

  本发明涉及抑制、调节和/或调节酪氨酸激酶信号转导的化合物，包含这些化合物的组合物，以及使用它们治疗哺乳动物的酪氨酸激酶依赖性疾病和状况，例如血管生成、癌症、肿瘤生长、动脉硬化、年龄相关性黄斑变性、糖尿病性视网膜病变、炎症性疾病等的方法。
• [EN] (METHYLSULFONYL)PHENYL-2-(5H)-FURANONES AS COX-2 INHIBITORS<br/>[FR] (METHYLSULFONYL)PHENYL-2-(5H)-FURANONES EN TANT QU'INHIBITEURS DU COX-2
  申请人：MERCK FROSST CANADA INC.

  公开号：WO1997014691A1

  公开（公告）日：1997-04-24

  (EN) The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).(FR) Cette invention, qui porte sur le nouveau composé répondant à la formule (I), composé s'avérant efficace dans le traitement de maladies liées à la cyclo-oxygénase-2, a également trait à certaines compositions pharmaceutiques qui, contenant des composés de ladite formule (I), servent à traiter lesdites maladies.

  该发明涉及一种新的化合物(I)的使用，该化合物可用于治疗环氧合酶-2介导的疾病。该发明还涉及一些药物组合物，用于治疗环氧合酶-2介导的疾病，其中包括化合物(I)。
• Nr2b receptor antagonists for the treatment or prevention of migraines
  申请人：——

  公开号：US20040204341A1

  公开（公告）日：2004-10-14

  The present invention encompasses a method for treating or preventing migraines in a mammalian patient in need of such treatment or prevention comprising administering to said patient an NR2B receptor antagonist in an amount that is effective to treat or prevent migraines. The invention also encompasses the combination of an NR2B antagonist with a cyclooxygenase-2 selective inhibitor, a calcitonin gene-related peptide receptor (CGRP) ligand, a leukotriene receptor antagonist or a 5HT 1B/1D agonist for the treatment or prevention of migraines.

  本发明涵盖了一种治疗或预防哺乳动物患者偏头痛的方法，包括向该患者施用有效治疗或预防偏头痛的NR2B受体拮抗剂。该发明还涵盖了将NR2B拮抗剂与环氧合酶2选择性抑制剂、降钙素基因相关肽受体（CGRP）配体、白三烯受体拮抗剂或5HT1B/1D激动剂结合使用，用于治疗或预防偏头痛。