trans 3-(3-trifluoromethyl-4-fluorophenyl)-2-propenoic acid chloride | 695187-01-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: trans 3-(3-trifluoromethyl-4-fluorophenyl)-2-propenoic acid chloride
• 英文别名: (E)-3-[4-fluoro-3-(trifluoromethyl)phenyl]prop-2-enoyl chloride
• CAS: 695187-01-0
• 化学式: C₁₀H₅ClF₄O
• 分子量: 252.596
• InChiKey: BLAIKKALLYIUAS-DUXPYHPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS
  申请人：Nardi Antonio

  公开号：US20100087496A1

  公开（公告）日：2010-04-08

  This invention relates to novel cinnamic amide derivatives that are found to be potent modulators of ion channels and, as such, they are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to modulation of ion channels.

  本发明涉及新型肉桂酰胺衍生物，发现它们是离子通道的强效调节剂，因此它们是治疗各种对离子通道调节有响应的疾病或疾病的有价值候选药物。
• [EN] BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE ACID DERIVATIVES AND THEIR USE AS HEPARANASE INHIBITORS<br/>[FR] DERIVES D'ACIDES DE BENZOXAZOLE, DE BENZOTHIAZOLE, ET DE BENZIMIDAZOLE PHARMACEUTIQUEMENT ACTIFS
  申请人：OXFORD GLYCOSCIENCES UK LTD

  公开号：WO2004046122A2

  公开（公告）日：2004-06-03

  Compounds of formula (I): wherein R1, R2 and R3 are independently, hydrogen, halogen, CF3, OR6, NR7R8, NR8COR10, NR8SO2R10 or C1-6 alkyl optionally substituted by hydroxy, C1-6 alkoxy or NR7R8; R4 is NR8CONR8R9, NR8COR9, NR8SO2R9, or W-CONR8R9, where W is a bond, C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene; and R5 is Formula (A) methods for their synthesis, pharmaceutical compositions comprising them and their use in medicine, in particular for the treatment of cancer.
• [EN] NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS<br/>[FR] NOUVEAUX DÉRIVÉS AMIDE CINNAMIQUES CONVENANT COMME MODULATEURS DES CANAUX IONIQUES
  申请人：NEUROSEARCH AS

  公开号：WO2008074755A2

  公开（公告）日：2008-06-26

  [EN] This invention relates to novel cinnamic amide derivatives that are found to be potent modulators of ion channels and, as such, they are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to modulation of ion channels.
  [FR] La présente invention concerne de nouveaux dérivés amide cinnamiques qui s'avèrent être de puissants modulateurs des canaux ioniques, et qui, en tant que tels, constituent des candidats intéressants pour le traitement de maladies et de troubles aussi divers que ceux qui réagissent à la modulation des canaux ioniques.