9-trifluoromethyl-7-methoxy-1,2,3,4-tetrahydroacridine | 1193132-14-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-trifluoromethyl-7-methoxy-1,2,3,4-tetrahydroacridine
• 英文别名: 7-Methoxy-9-(trifluoromethyl)-1,2,3,4-tetrahydroacridine
• CAS: 1193132-14-7
• 化学式: C₁₅H₁₄F₃NO
• 分子量: 281.277
• InChiKey: RDVIFWUOYUOEJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-trifluoroacetyl-1-(4-methoxyphenylamino)-cyclohexene 在 PPA 作用下， 以20%的产率得到9-trifluoromethyl-7-methoxy-1,2,3,4-tetrahydroacridine
  参考文献：
  名称：

  Synthesis of New Fluorine-Containing 1,2,3,4-Tetrahydroacridines

  摘要：

  A convenient method for the synthesis of a novel series of four 5-trilfluoromethyl-1,2,3,4-tetrahydroacridines, by intramolecular cyclization reactions of 2-trifluoroacetyl-1-(arylamino)-cyclohexene using polyphosphoric acid (PPA), is described. The six new enaminoketone intermediates were obtained by an oxygen-nitrogen exchange reaction from 2-trifluoroacetyl-1-methoxycyclohexene with six 4-substituted anilines.

  DOI：

  10.1080/00397910902803692

文献信息

• Synthesis of New Fluorine-Containing 1,2,3,4-Tetrahydroacridines
  作者：Helio Gauze Bonacorso、Tatiana Soldati de Moraes、Nilo Zanatta、Marcos Antonio Pinto Martins

  DOI：10.1080/00397910902803692

  日期：2009.9.18

  A convenient method for the synthesis of a novel series of four 5-trilfluoromethyl-1,2,3,4-tetrahydroacridines, by intramolecular cyclization reactions of 2-trifluoroacetyl-1-(arylamino)-cyclohexene using polyphosphoric acid (PPA), is described. The six new enaminoketone intermediates were obtained by an oxygen-nitrogen exchange reaction from 2-trifluoroacetyl-1-methoxycyclohexene with six 4-substituted anilines.