| 1415663-33-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1415663-33-0
• 化学式: C₁₈H₂₄FNO₄
• 分子量: 337.391
• InChiKey: DACGWFQCHUYLEP-SWAGJOJWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.43
• 重原子数：
  24.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  48.0
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  、 11,12-carbonate-11,12-dideoxy-5-hydroxyl-3-oxo-6-O-methyl-erythronolide A 在 二氯二茂铪 、 silver perchlorate 作用下， 以 二氯甲烷 为溶剂， 反应 96.25h， 以26%的产率得到5-(4-O-allyl-2-O-benzoyl-mycaminosyl)-3-O-descladinosyl-6-O-methyl-3-oxo-erythronolide A 11,12-cyclic carbonate
  参考文献：
  名称：

  Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides

  摘要：

  A series of novel modified 5-O-desosamine-ketolides were synthesized. The 5-O-desosamine fragment was removed from ketolide by an efficient and mild manipulation. 4-O-substituted desosamine was introduced into the ketolide aglycon and various coupling methods were essayed for the glycosylation. Three novel ketolides were tested for in vitro antibacterial activity against a panel of susceptible and resistant pathogens. Compound 26 showed potent activity against all the methicillin-sensitivity and resistant pathogens. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.10.064