triethylammonium pivalate | 67693-93-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: triethylammonium pivalate
• 英文别名: 2,2-dimethylpropanoate;triethylazanium
• CAS: 67693-93-0
• 化学式: C₅H₁₀O₂*C₆H₁₅N
• 分子量: 203.325
• InChiKey: NMMUKCBUAZXNFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.47
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7,7-dichloro-cis-bicyclo<4.2.0>octane-8-one 、 triethylammonium pivalate 生成 [(1R,6R,7S)-7-chloro-8-oxo-1-bicyclo[4.2.0]octanyl] 2,2-dimethylpropanoate
  参考文献：
  名称：

  HASSNER, A.;DILLON, J. L. ,, JR;KREPSKI, L. R.;ONAN, K. D., TETRAHEDRON LETT., 1983, 24, N 11, 1135-1138

  摘要：

  DOI：
• 作为产物：
  描述：

  三乙胺 、 三甲基乙酸 以 正己烷 为溶剂， 反应 24.0h， 生成 triethylammonium pivalate
  参考文献：
  名称：

  Molecular structures of triethylamine complexes with benzoic and pivalic acids

  摘要：

  Dissolution of benzoic or pivalic acid in excess triethylamine followed by crystallization was found to yield single crystals of 1: 1 and 1: 2 complexes, respectively. X-ray crystallography have shown that the complex with benzoic acid is an (Et3NH)(+)(OOCPh)(-) ion pair, in which the proton is transfered from the acid to the base (Na <-O 2.629(2) ), and the complex with pivalic acid contains, in addition to the ion pair (Na <-O 2.649 ), the homoconjugate anion ((BuCOO)-C-t)(H)(OOCBut)(-) (Oa <-O 2.521 ).

  DOI：

  10.1134/s0036023610080127

文献信息

• Effect of conformation and stereochemistry in substitution reactions of fused chlorocyclobutanones: oxyallyl cation intermediates
  作者：Alfred Hassner、John L Dillon、Larry R Krepski、Kay D Onan

  DOI：10.1016/s0040-4039(00)86385-6

  日期：1983.1

  Fused α-acyloxycyclobutanones, whose conformation and stereochemistry have been unambiguously established by X-ray analysis, undergo an unusual displacement with methoxide as nucleophile to produce α-methoxycyclobutanones. The success of this reaction, which suggests the intermediacy of an oxyallyl cation, is highly dependent on conformational and steric factors.

  通过X射线分析已明确确定其构象和立体化学的熔融α-酰氧基环丁酮，经过以甲醇盐作为亲核试剂的不寻常置换，生成α-甲氧基环丁酮。该反应的成功表明了羟基烯丙基阳离子的中间性，在很大程度上取决于构象和空间因素。
• Salts of 7-aminocephalosporanic acids, soluble in organic solvents and their use in the preparation of cephalosporins
  申请人：GEMA S.A.

  公开号：EP0053077A2

  公开（公告）日：1982-06-02

  New salts of 7-aminocephalosporanic acids of general formula wherein R1 is among others H, CH3 or CH3O; R2 is among others CH3, CH30, Cl, azidomethyl, carbamoylmethyl, acetoxymethyl, thiomethyl, phenylthiomethyl, aliphatic, aromatic or heteroxyclic methylthiocarbonyl or methylthiohetero- cycle ; x is 3 to 5 ; and y is 2 to 4, in solution in an organic solvent, are used in the preparation of cephalosporins.

  通式为 7-氨基头孢烷酸的新盐 其中 R1 是 H、CH3 或 O；R2 是 、 0、Cl、叠氮甲基、氨基甲酰基甲基、乙酰氧甲基、硫甲基、苯硫甲基、脂肪族、芳香族或杂环甲基硫代羰基或甲基硫代杂环；x 是 3 至 5；y 是 2 至 4，在有机溶剂中的溶液可用于制备头孢菌素。
• Salts of amino-beta-lactamic acids and process for the preparation thereof
  申请人：GEMA S.A.

  公开号：EP0127541A2

  公开（公告）日：1984-12-05

  Amino-beta-lactamic acid salts, having the formula: wherein: (X-Y) may form a system having from 1 to 3 carbon atoms, with or without double bond, a) closed, in which: X is an atom selected from among carbon, oxygen, nitrogen and sulphur; Y is methylene; Z is a carboxy, sulphonic or phosphonic group. b) open, which may comprise a double bond, in which: X is an atom of hydrogen or a methyl, hydroxymethyl or thiol group, Y is an acid radical chosen from the group formed by sulphonic, phosphonic and sulphoamidic acid; Z is missing. R is an atom or hydrogen, or a methoxyl or ethoxyl group. R is, when present, methyl, acetoxymethyl, acylthiomethyl, such as acetyl and benzoyl derivatives, methoxy, chlorine, carbamoyloxymethyl, azido, azidomethyl (alpha, beta)-thioethylamine or a thiomethyl-heterocyclic derivative of the thiazole, thiadiazole, triazole, tetrazole, oxazole, oxadiazole, pyrimidine and imidazole nuclei. R2 is an atom of hydrogen or a methyl, ethyl, benzyl or aryl group. m, n may be the same or different and may range from 1 to 4, forming a ring or m = n = 0 to form an open chain. A process for their preparation is also disclosed.

  具有以下式子的氨基-beta-乳酸盐 其中(X-Y)可构成一个具有 1 至 3 个碳原子的体系，具有或不具有双键，a) 封闭，其中：a) 封闭式，其中：X 是选自碳、氧、氮和硫的原子；Y 是亚甲基；Z 是羧基、磺酸基或膦酸基：X 是氢原子或甲基、羟甲基或硫醇基；Y 是酸基，选自磺酸、膦酸和磺酰胺酸组成的基团；Z 缺失。R 是原子或氢、甲氧基或乙氧基。R 是甲基、乙酰氧甲基、酰硫基甲基（如乙酰基和苯甲酰衍生物）、甲氧基、氯、氨基甲酰氧甲基、叠氮、叠氮甲基（α，β）-硫代乙胺或噻唑、噻二唑、三唑、四唑、噁唑、噁二唑、嘧啶和咪唑核的硫代甲基三环衍生物。m、n 可以相同或不同，范围从 1 到 4，形成一个环或 m = n = 0 形成一个开放链。此外，还公开了其制备工艺。
• Methods for reducing non-specific binding to an oligonucleotide array
  申请人：——

  公开号：US20010049108A1

  公开（公告）日：2001-12-06

  The present invention provides a variety of methods for reducing non-specific binding of a target molecule or plurality of target molecules to an array of oligonucleotides. The methods of the present invention include surface modification techniques and oligonucleotide modification techniques. According to one method of the present invention, non-specific binding of a target molecule to an array of oligonucleotides is reduced by replacing at least one of: i) the protecting groups on each of the plurality of oligonucleotides, and ii) the protecting groups on each of the protected regions of the substrate, with a negatively charged phosphate residue.

  本发明提供了多种减少目标分子或多个目标分子与寡核苷酸阵列非特异性结合的方法。本发明的方法包括表面修饰技术和寡核苷酸修饰技术。根据本发明的一种方法，通过用带负电荷的磷酸残基取代以下至少一种，可减少目标分子与寡核苷酸阵列的非特异性结合：i）多个寡核苷酸中每个寡核苷酸上的保护基团；ii）底物的每个保护区上的保护基团。
• PREPARATION OF AN ATORVASTATIN INTERMEDIATE USING A PAAL-KNORR CONDENSATION
  申请人：C.P. Pharmaceuticals International C.V.

  公开号：EP1861364B1

  公开（公告）日：2011-05-11