rac-N5-(2-methanesulfonyl-ethyl)-N2-(6-methoxy-indan-1-yl)-quinoline-2,5-diamine | 1186320-23-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: rac-N5-(2-methanesulfonyl-ethyl)-N2-(6-methoxy-indan-1-yl)-quinoline-2,5-diamine
• 英文别名: 2-N-(6-methoxy-2,3-dihydro-1H-inden-1-yl)-5-N-(2-methylsulfonylethyl)quinoline-2,5-diamine
• CAS: 1186320-23-9
• 化学式: C₂₂H₂₅N₃O₃S
• 分子量: 411.525
• InChiKey: KLLIFHXACYSTCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  88.7
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• 2-AMINOQUINOLINE DERIVATIVES
  申请人：Kolczewski Sabine

  公开号：US20090227584A1

  公开（公告）日：2009-09-10

  The present invention is concerned with 2-aminoquinoline derivatives, in particular compounds of formula (I) wherein R 1 and R 2 are as described herein, pharmaceutical compositions containing such compounds, and methods for their manufacture. The compounds of the invention are 5-HT 5A receptor antagonists useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.

  本发明涉及2-氨基喹啉衍生物，特别是具有式(I)的化合物，其中R1和R2如本文所述，含有这种化合物的药物组合物，以及它们的制备方法。本发明的化合物是5-HT5A受体拮抗剂，在预防和/或治疗抑郁症、焦虑障碍、精神分裂症、恐慌障碍、广场恐惧症、社交恐惧症、强迫性障碍、创伤后应激障碍、疼痛、记忆障碍、痴呆、进食行为障碍、性功能障碍、睡眠障碍、药物滥用、帕金森病等运动障碍、精神障碍或胃肠道障碍的预防和/或治疗中有用。