[(4R,6R)-6-benzyl-2,2-dimethyl-1,3-dioxan-4-yl]methoxy-tert-butyl-diphenylsilane | 1150312-97-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(4R,6R)-6-benzyl-2,2-dimethyl-1,3-dioxan-4-yl]methoxy-tert-butyl-diphenylsilane
• CAS: 1150312-97-2
• 化学式: C₃₀H₃₈O₃Si
• 分子量: 474.715
• InChiKey: ZEKIOQUZWBNHAJ-CLJLJLNGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.72
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [(4R,6R)-6-benzyl-2,2-dimethyl-1,3-dioxan-4-yl]methoxy-tert-butyl-diphenylsilane 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 以87%的产率得到[(4R,6R)-6-benzyl-2,2-dimethyl-1,3-dioxan-4-yl]methanol
  参考文献：
  名称：

  Chemoenzymatic asymmetric synthesis of harzia lactone A stereomers

  摘要：

  A facile chemoenzymatic synthesis of the harzia lactone A enantiomers was developed. A lipase-catalyzed acylation and an enantio-controlled substrate and reagent-con trol led Sharpless' asymmetric dihydroxylation are the key features of the synthesis. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.01.009
• 作为产物：
  描述：

  2,2-二甲氧基丙烷 、 (2R,4R)-1-[tert-butyl(diphenyl)silyl]oxy-5-phenylpentane-2,4-diol 在 4-甲基苯磺酸吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以85%的产率得到[(4R,6R)-6-benzyl-2,2-dimethyl-1,3-dioxan-4-yl]methoxy-tert-butyl-diphenylsilane
  参考文献：
  名称：

  Chemoenzymatic asymmetric synthesis of harzia lactone A stereomers

  摘要：

  A facile chemoenzymatic synthesis of the harzia lactone A enantiomers was developed. A lipase-catalyzed acylation and an enantio-controlled substrate and reagent-con trol led Sharpless' asymmetric dihydroxylation are the key features of the synthesis. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.01.009

文献信息

• Chemoenzymatic asymmetric synthesis of harzia lactone A stereomers
  作者：Abha N. Kumar、Suchitra Bhatt、Subrata Chattopadhyay

  DOI：10.1016/j.tetasy.2009.01.009

  日期：2009.2

  A facile chemoenzymatic synthesis of the harzia lactone A enantiomers was developed. A lipase-catalyzed acylation and an enantio-controlled substrate and reagent-con trol led Sharpless' asymmetric dihydroxylation are the key features of the synthesis. (C) 2009 Elsevier Ltd. All rights reserved.