| 1061181-41-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1061181-41-6
• 化学式: C₁₅H₂₀Cl₃NO₈
• 分子量: 448.685
• InChiKey: NZPXRUCDLVGSIK-PRFVCTMUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.21
• 重原子数：
  27.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  109.39
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  2-deoxy-4,6-O-isopropylidene-2-(2,2,2-trichloroacetamido)-D-glucopyranose 、 乙酸酐 在 吡啶 作用下， 生成 、 1,3-di-O-acetyl-2-deoxy-4,6-O-isopropylidene-2-(2,2,2-trichloroacetamido)-D-glucopyranose
  参考文献：
  名称：

  Efficient route to orthogonally protected precursors of 2-acylamino-2-deoxy-3-O-substituted-β-d-glucopyranose derivatives and use thereof

  摘要：

  An efficient route to two 3-O-acyl-2-deoxy-4,6-O-isopropylidene-2-trichloroacetamido-D-glucopyranosyl trichloroacetimidate donors is reported. As demonstrated for the 3-O-acetyl derivative, these building blocks are exquisite beta-D-glucosamine donors when reacted either with simple alcohols or with complex oligosaccharides. Besides, their protection pattern is compatible with selective deprotection and subsequent chain elongation at O-3 of the newly incorporated glucosamine residue. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.06.052