盐酸利托菌 | 4635-27-2

• 物质功能分类: 原料药 - 激素及调节内分泌功能类药 - 垂体激素类药
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 盐酸利托菌
• 英文名称: Ritodrin
• 英文别名: ritodrine；(-)-erythro-1-(p-hydroxyphenyl)-2-[2-(p-hydroxyphenyl)ethylamino]-1-propanol；4-[1-hydroxy-2-[2-(4-hydroxyphenyl)ethylamino]propyl]phenol；4-[2-[[1-Hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol
• CAS: 4635-27-2
• 化学式: C₁₇H₂₁NO₃
• 分子量: 287.359
• InChiKey: IOVGROKTTNBUGK-UHFFFAOYSA-N

物化性质

• 沸点：
  512.3±45.0 °C(Predicted)
• 密度：
  1.213±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  72.7
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Pyrrolidine oxadiazole-and thiadiazole derivatives
  申请人：——

  公开号：US20040220238A1

  公开（公告）日：2004-11-04

  The present invention is related to pyrrolidine oxadiazole and thiadiazole derivatives for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such pyrrolidine oxadiazole derivatives. Said pyrrolidine derivatives are useful in the treatment and/or prevention of preterm labor, premature birth and dysmenorrhea. In particular, the present invention is related to pyrrolidine derivatives displaying a substantial modulatory, notably an antagonist activity of the oxytocin receptor. More preferably, said compounds are useful in the treatment and/or prevention of disease states mediated by oxytocin, including preterm labor, premature birth and dysmenorrhea. The present invention is furthermore related to novel pyrrolidine derivatives as well as to methods of their preparation. (I) B is a oxadiazole or thiadiazole group. 1

  本发明涉及吡咯烷氧二唑和噻二唑衍生物，用作药物活性化合物，以及含有此类吡咯烷氧二唑衍生物的制药配方。所述吡咯烷衍生物在治疗和/或预防早产、早产和痛经方面具有用途。特别地，本发明涉及显示出显著调节活性，特别是催产素受体拮抗剂活性的吡咯烷衍生物。更具体地，这些化合物在治疗和/或预防由催产素介导的疾病状态方面具有用途，包括早产、早产和痛经。本发明还涉及新型吡咯烷衍生物及其制备方法。(I) B是氧代二唑或噻二唑基团。
• Pyrrolidine oxadiazole-and thiadiazole oxime derivatives being oxytocin receptor antagonists
  申请人：Schwarz Matthias

  公开号：US20060229343A1

  公开（公告）日：2006-10-12

  The present invention is related to pyrrolidine oxadiazole and thiadiazole derivatives for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such pyrrolidine oxadiazole derivatives. Said pyrrolidine derivatives are useful in the treatment and/or prevention of preterm labor, premature birth and dysmenorrhea. In particular, the present invention is related to pyrrolidine derivatives displaying a substantial modulatory, notably an antagonist activity of the oxytocin receptor. More preferably, said compounds are useful in the treatment and/or prevention of disease states mediated by oxytocin, including preterm labor, premature birth and dysmenorrhea. The present invention is furthermore related to novel pyrrolidine derivatives as well as to methods of their preparation. B is a oxadiazole or thiadiazole group.

  本发明涉及吡咯烷氧噻二唑和噻二唑衍生物，用作药物活性化合物，以及包含此类吡咯烷氧噻二唑衍生物的制药配方。所述吡咯烷衍生物在治疗和/或预防早产、早产和痛经方面具有用途。特别是，本发明涉及显示出 oxytocin 受体的重要调节作用，特别是拮抗剂活性的吡咯烷衍生物。更具体地说，所述化合物在治疗和/或预防由 oxytocin 介导的疾病状态方面具有用途，包括早产、早产和痛经。本发明还涉及新的吡咯烷衍生物以及它们的制备方法。B 是一个氧噻二唑或噻二唑基团。
• (-)-RITODRINE
  申请人：MEIJI SEIKA KABUSHIKI KAISHA

  公开号：EP0603414A1

  公开（公告）日：1994-06-29

  (-)-Ritodrine, i.e. (-)-erythro-1-(p-hydroxyphenyl)-2-[2-(p-hydroxyphenyl)ethylamino]-1-propanol, which is substantially free from the (+)-isomer, or a salt thereof. This compound has a potent effect of inhibiting uterine contraction as compared with (±)-ritodrine and (+)-ritodrine and a toxicity comparable to those of the other ritodrines, and hence is usable as a highly safe remedy for threatened premature birth and abortion and a remedy for dysmenorrhea.

  (-)-利托君，即(-)-赤式-1-(对羟基苯基)-2-[2-(对羟基苯基)乙氨基]-1-丙醇，基本上不含(+)-异构体，或其盐。与(±)-利托君和(+)-利托君相比，该化合物具有抑制子宫收缩的强效作用，毒性与其他利托君相似，因此可作为一种高度安全的治疗早产和流产的药物以及治疗痛经的药物。
• [EN] (-)-RITODRINE<br/>[FR] (-)-RITODRINE
  申请人：MEIJI SEIKA KABUSHIKI KAISHA

  公开号：WO1994001392A1

  公开（公告）日：1994-01-20

  (EN) (-)-Ritodrine, i.e. (-)-erythro-1-(p-hydroxyphenyl)-2-[2-(p-hydroxyphenyl)ethylamino]-1-propanol, which is substantially free from the (+)-isomer, or a salt thereof. This compound has a potent effect of inhibiting uterine contraction as compared with (±)-ritodrine and (+)-ritodrine and a toxicity comparable to those of the other ritodrines, and hence is usable as a highly safe remedy for threatened premature birth and abortion and a remedy for dysmenorrhea.(FR) (-)-ritodrine, c'est-à-dire le (-)-érythro-1-(p-hydroxyphényl)-2-[2-(p-hydroxyphényl)éthylamino]-1-propanol, sensiblement exempt du (+)-isomère, ou d'un sel de celui-ci. Ce composé présente un effet d'inhibition de la contraction utérine plus puissant que celui de la (±)-ritodrine et de la (+)-ritodrine, ainsi qu'une toxicité comparable à celle des autres ritodrines. Il est donc utilisable comme remède très sûr en cas de risque d'une naissance avant-terme ou d'un avortement, et comme remède contre la dysménorrhée.

  (-)-里托德 undergraduate，即(-)- erythro-1-(p-羟基苯基)-2-[2-(p-羟基苯基)氨基]-1-丙醇，其基本成分几乎是或可形成无（+）-异构体的盐。此化合物对抗（±）—里托德 undergraduate 以抑制子宫收缩的效果更强，并且其毒性与对其他里托德类药物的毒性相当，因此可用于极其安全地治疗threatened premature birth（早期难产）和 abortion，以及治疗menstrual cramps（经期疼痛）。
• Phenethanolamine-derived haptens, immunogens and conjugates comprising them and antibodies recognising said immunogenes and conjugates
  申请人：Randox Laboratories Ltd.

  公开号：EP1657235B1

  公开（公告）日：2011-09-21