2-Amino-1-(4-methoxy-3-nitrophenyl)ethanone hydrochloride | 877395-19-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Amino-1-(4-methoxy-3-nitrophenyl)ethanone hydrochloride
• 英文别名: 2-amino-1-(4-methoxy-3-nitrophenyl)ethanone;hydrochloride
• CAS: 877395-19-2
• 化学式: C₉H₁₀N₂O₄*ClH
• 分子量: 246.65
• InChiKey: JOTOORYFPZZYBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.17
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  98.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Amino-1-(4-methoxy-3-nitrophenyl)ethanone hydrochloride 、 乙酸酐 在 sodium acetate 作用下， 以 水 为溶剂， 生成 N-(2-(4-methoxy-3-nitrophenyl)-2-oxoethyl)acetamide
  参考文献：
  名称：

  Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents

  摘要：

  A new series of aryl substituted imidazol-2-one derivatives structurally related to combretastatin A-4 (CA-4) were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines including MDR cell line. The cytotoxic effects of compounds 7b and 7i proved to be similar to or greater than that of docetaxel. The highly active compound 7b also exhibited excellent inhibitory activity on tumor growth in vivo. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2007.11.048
• 作为产物：
  描述：

  2-溴-1-(4-甲氧基-3-硝基苯基)乙酮 在 乌洛托品 、 盐酸 作用下， 以 氯仿 、 乙醇 为溶剂， 反应 2.0h， 生成 2-Amino-1-(4-methoxy-3-nitrophenyl)ethanone hydrochloride
  参考文献：
  名称：

  Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents

  摘要：

  A new series of aryl substituted imidazol-2-one derivatives structurally related to combretastatin A-4 (CA-4) were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines including MDR cell line. The cytotoxic effects of compounds 7b and 7i proved to be similar to or greater than that of docetaxel. The highly active compound 7b also exhibited excellent inhibitory activity on tumor growth in vivo. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2007.11.048

文献信息

• Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents
  作者：Na Xue、Xiaochun Yang、Rui Wu、Jing Chen、Qiaojun He、Bo Yang、Xiuyang Lu、Yongzhou Hu

  DOI：10.1016/j.bmc.2007.11.048

  日期：2008.3

  A new series of aryl substituted imidazol-2-one derivatives structurally related to combretastatin A-4 (CA-4) were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines including MDR cell line. The cytotoxic effects of compounds 7b and 7i proved to be similar to or greater than that of docetaxel. The highly active compound 7b also exhibited excellent inhibitory activity on tumor growth in vivo. (C) 2008 Published by Elsevier Ltd.