N-((2S,6S,9S,14aS,16S,20S,23S,25aS)-2,16-diazido-6,20-bis((R)-1-hydroxyethyl)-23-(4-hydroxyphenethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-6-(pentyloxy)-2-naphthamide | 1203557-01-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: N-((2S,6S,9S,14aS,16S,20S,23S,25aS)-2,16-diazido-6,20-bis((R)-1-hydroxyethyl)-23-(4-hydroxyphenethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-6-(pentyloxy)-2-naphthamide
• CAS: 1203557-01-0
• 化学式: C₄₉H₆₃N₁₃O₁₁
• 分子量: 1010.12
• InChiKey: IKZIWQXQALJZGV-KPFUITJBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.53
• 重原子数：
  73.0
• 可旋转键数：
  14.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  353.56
• 氢给体数：
  8.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  N-((2S,6S,9S,14aS,16S,20S,23S,25aS)-2,16-diazido-6,20-bis((R)-1-hydroxyethyl)-23-(4-hydroxyphenethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-6-(pentyloxy)-2-naphthamide 、 对甲苯磺酸 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以84%的产率得到
  参考文献：
  名称：

  Total synthesis and structure–activity relationships of new echinocandin-like antifungal cyclolipohexapeptides

  摘要：

  A series of new echinocandin-like cyclolipohexapeptides were designed and total synthesized via solution phase [3 + 3]-segment coupling strategy with an attempt to improve antifungal activity. The designed compounds showed potent antifungal activities with broad spectrum. In particular, 11 compounds (i.e. 28a-e, 28g, 28i-j, 29a, 29c and 29e) showed better in vitro antifungal activities against Candida albicans or Aspergillus fumigatus than caspofungin. Moreover, the synthesized compounds provided new SAR information for the echinocandins. The findings in this work suggested that the "left" tripeptide segment of cyclolipohexapeptide scaffold might be a hydrophilic structural motif, whereas the "right" lipopeptide segment was preferred as a hydrophobic core. The amino acid component of the cyclolipohexapeptide scaffold could significantly affect the SAR of the side chains. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.01.054
• 作为产物：
  描述：

  methyl (2S,4S)-4-azido-1-(((S)-5-((2S,4S)-4-azido-1-(((S)-2-((tert-butoxycarbonyl)amino)-4-(4-hydroxyphenyl)butanoyl)-L-threonyl)pyrrolidine-2-carboxamido)-2-(6-(pentyloxy)-2-naphthamido)pentanoyl)-L-threonyl)pyrrolidine-2-carboxylate 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 1-羟基苯并三唑 、 N,N-二异丙基乙胺 、 三氟乙酸 、 sodium hydroxide 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 49.0h， 生成 N-((2S,6S,9S,14aS,16S,20S,23S,25aS)-2,16-diazido-6,20-bis((R)-1-hydroxyethyl)-23-(4-hydroxyphenethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-6-(pentyloxy)-2-naphthamide
  参考文献：
  名称：

  Total synthesis and structure–activity relationships of new echinocandin-like antifungal cyclolipohexapeptides

  摘要：

  A series of new echinocandin-like cyclolipohexapeptides were designed and total synthesized via solution phase [3 + 3]-segment coupling strategy with an attempt to improve antifungal activity. The designed compounds showed potent antifungal activities with broad spectrum. In particular, 11 compounds (i.e. 28a-e, 28g, 28i-j, 29a, 29c and 29e) showed better in vitro antifungal activities against Candida albicans or Aspergillus fumigatus than caspofungin. Moreover, the synthesized compounds provided new SAR information for the echinocandins. The findings in this work suggested that the "left" tripeptide segment of cyclolipohexapeptide scaffold might be a hydrophilic structural motif, whereas the "right" lipopeptide segment was preferred as a hydrophobic core. The amino acid component of the cyclolipohexapeptide scaffold could significantly affect the SAR of the side chains. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.01.054