4-methyl-N-(3-oxo-3-phenyl-1-(thiophen-2-yl)propyl)benzenesulfonamide | 1198790-82-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methyl-N-(3-oxo-3-phenyl-1-(thiophen-2-yl)propyl)benzenesulfonamide
• 英文别名: 4-methyl-N-(3-oxo-3-phenyl-1-thiophen-2-ylpropyl)benzenesulfonamide
• CAS: 1198790-82-7
• 化学式: C₂₀H₁₉NO₃S₂
• 分子量: 385.508
• InChiKey: LZULPULITJAYOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  99.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  苯乙酮 、 4-methyl-N-(thiophen-2-ylmethylene)benzenesulfonamide 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 以80%的产率得到4-methyl-N-(3-oxo-3-phenyl-1-(thiophen-2-yl)propyl)benzenesulfonamide
  参考文献：
  名称：

  Simple and Efficient Access to N-Tosyl β-Amino Ketones and Their Conversion into 2,4-Disubstituted Azetidines

  摘要：

  Treatment of N-tosylaldimines with acetophenone at room temperature in the presence of Bf(3)center dot OEt2 as a catalyst furnished the corresponding N-tosyl beta-amino ketones in high yields (77-86%) within 6-9 h. Subsequent reduction and cyclization of these compounds afforded 2,4-disubstituted N-tosylazetidines, comprising a three-step, high-yielding synthesis starting from aldimines.

  DOI：

  10.1021/jo901982n

文献信息

• Simple and Efficient Access to <i>N</i>-Tosyl β-Amino Ketones and Their Conversion into 2,4-Disubstituted Azetidines
  作者：Biswanath Das、Penagaluri Balasubramanyam、Boyapati Veeranjaneyulu、Gandolla Chinna Reddy

  DOI：10.1021/jo901982n

  日期：2009.12.18

  Treatment of N-tosylaldimines with acetophenone at room temperature in the presence of Bf(3)center dot OEt2 as a catalyst furnished the corresponding N-tosyl beta-amino ketones in high yields (77-86%) within 6-9 h. Subsequent reduction and cyclization of these compounds afforded 2,4-disubstituted N-tosylazetidines, comprising a three-step, high-yielding synthesis starting from aldimines.