4-[4-(3,4-dihydroquinolin-1(2H)-yl)-4-oxobutoxy]indan-1-ol | 878291-52-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-[4-(3,4-dihydroquinolin-1(2H)-yl)-4-oxobutoxy]indan-1-ol
• 英文别名: 1-(3,4-dihydro-2H-quinolin-1-yl)-4-[(1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy]butan-1-one
• CAS: 878291-52-2
• 化学式: C₂₂H₂₅NO₃
• 分子量: 351.445
• InChiKey: ARNHUQZNTLCQOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• THERAPEUTIC AGENT FOR IRRITABLE BOWEL SYNDROME
  申请人：Maruyama Minoru

  公开号：US20110136788A1

  公开（公告）日：2011-06-09

  [Problem] The present invention aims to provide an agent for the prophylaxis or treatment of irritable bowel syndrome. [Solving Means] An agent for the prophylaxis or treatment of irritable bowel syndrome, containing a compound having a TGR5 receptor agonist activity, a fused ring compound represented by the formula wherein ring A is an optionally substituted aromatic ring, and ring B′ is a 5- to 9-membered ring having one or more substituents, or a salt thereof as an active ingredient.