4-[[1-[2-(1H-indol-3-yl)ethyl]-4-methyl-2,3-dihydroquinoxalin-6-yl]amino]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol | 1135827-54-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-[[1-[2-(1H-indol-3-yl)ethyl]-4-methyl-2,3-dihydroquinoxalin-6-yl]amino]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol
• CAS: 1135827-54-1
• 化学式: C₂₇H₂₉N₅O
• 分子量: 439.56
• InChiKey: WCVJJNPEPXMLRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  67.4
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Inhibitors of the Interaction Between MDM2 and P53
  申请人：Storck Pierre-Henri

  公开号：US20100216770A1

  公开（公告）日：2010-08-26

  The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds: wherein n, s, t, R 1 , R 2 , R 3 , R 4 , R 5 , X, Y, Q, Z, G, E and D have defined meanings.
• INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53
  申请人：Storck Pierre Henri

  公开号：US20130005769A1

  公开（公告）日：2013-01-03

  The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds: wherein n, s, t, R 1 , R 2 , R 3 , R 4 , R 5 , X, Y, Q, Z, G, E and D have defined meanings.
• US8288377B2
  申请人：——

  公开号：US8288377B2

  公开（公告）日：2012-10-16