| 1072846-98-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1072846-98-0
• 化学式: C₁₃H₁₇Br₄NO₂
• 分子量: 538.899
• InChiKey: PDPNIVMDWXHNJR-FXAINCCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.05
• 重原子数：
  20.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  30.49
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  、 3-溴丙烯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 N-prop-2-enyl-N-[[(1R,2R,4S)-1,4,5,6-tetrabromo-7,7-dimethoxy-2-bicyclo[2.2.1]hept-5-enyl]methyl]prop-2-en-1-amine
  参考文献：
  名称：

  A stereoselective C7nC5x free-radical cascade route to optically pure and potentially useful tetracyclic amines

  摘要：

  Nucleophilic racemic amines have been synthesized utilizing a (CC5x)-C-7n free-radical cascade reaction from a bis-allyl amine starting material. Being potentially useful organocatalytic bases as is evident from their screening in the Baylis-Hillman reaction, optically pure amines were also synthesized from optically pure aldehydes (-) or (+)-4. Bis-allyl amides under similar radical reaction condition resulted in C-7n cyclized products. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.08.013
• 作为产物：
  描述：

  在 sodium tetrahydroborate 作用下， 反应 4.0h， 生成
  参考文献：
  名称：

  A stereoselective C7nC5x free-radical cascade route to optically pure and potentially useful tetracyclic amines

  摘要：

  Nucleophilic racemic amines have been synthesized utilizing a (CC5x)-C-7n free-radical cascade reaction from a bis-allyl amine starting material. Being potentially useful organocatalytic bases as is evident from their screening in the Baylis-Hillman reaction, optically pure amines were also synthesized from optically pure aldehydes (-) or (+)-4. Bis-allyl amides under similar radical reaction condition resulted in C-7n cyclized products. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.08.013