Enantioselective decarboxylative aldol addition of β-ketoacids to isatins catalyzed by binaphthyl-modified organocatalyst
作者:Chang Won Suh、Chul Woo Chang、Keon Woong Choi、Young Jo Lim、Dae Young Kim
DOI:10.1016/j.tetlet.2013.04.132
日期:2013.7
The catalytic enantioselective decarboxylative aldol addition reaction of isatins with β-ketoacids promoted by chiral bifunctional organocatalysts have been developed, allowing facile synthesis of the corresponding chiral 3-hydroxy-3-phenacyloxindole derivatives with excellent enantioselectivity (up to 97% ee).