3-甲基-1-苯基-1H-吡唑-4,5-二胺 | 52943-88-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 3-甲基-1-苯基-1H-吡唑-4,5-二胺
• 英文名称: 4,5-diamino-3-methyl-1-phenylpyrazole
• 英文别名: 1-Phenyl-3-methyl-4,5-diamino-pyrazol；1-phenyl-3-methyl-4,5-diaminopyrazole；4,5-Diamino-3-methyl-1-phenyl-pyrazol；4,5-diamino-3-methyl-1-phenyl-1H-pyrazole；3-Methyl-1-phenyl-1h-pyrazole-4,5-diamine；5-methyl-2-phenylpyrazole-3,4-diamine
• CAS: 52943-88-1
• 化学式: C₁₀H₁₂N₄
• 分子量: 188.232
• InChiKey: JSVCLRZBHIRDNZ-UHFFFAOYSA-N

物化性质

• 熔点：
  119 °C
• 沸点：
  371.5±37.0 °C(Predicted)
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  69.9
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933199090

反应信息

• 作为反应物：
  描述：

  3-甲基-1-苯基-1H-吡唑-4,5-二胺 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以40%的产率得到1-phenyl-3-methyl-5-imino-4-<(1-phenyl-3-methyl-4-aminopyrazol-5-yl)imino>-2-pyrazoline
  参考文献：
  名称：

  Reactions of 4,5-diamino-3-methyl-1-phenylpyrazole with aromatic haloketones

  摘要：

  DOI：

  10.1007/bf00475599
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 tin(ll) chloride 作用下， 生成 3-甲基-1-苯基-1H-吡唑-4,5-二胺
  参考文献：
  名称：

  Michaelis; Klopstock, Justus Liebigs Annalen der Chemie, 1907, vol. 354, p. 109

  摘要：

  DOI：

文献信息

• An efficient synthesis of new caffeine-based chalcones, pyrazolines and pyrazolo[3,4-b][1,4]diazepines as potential antimalarial, antitrypanosomal and antileishmanial agents
  作者：Braulio Insuasty、Juan Ramírez、Diana Becerra、Carlos Echeverry、Jairo Quiroga、Rodrigo Abonia、Sara M. Robledo、Iván Darío Vélez、Yulieth Upegui、July A. Muñoz、Victoria Ospina、Manuel Nogueras、Justo Cobo

  DOI：10.1016/j.ejmech.2015.02.040

  日期：2015.3

  A new series of chalcones 5a–f were synthesized from caffeine-based aldehyde 3 and substituted acetophenones 4a–f. Treatment of compounds 5a–f with hydrazine hydrate led to pyrazolines 6a–f, and their subsequent reaction with acetic anhydride or formic acid afforded the corresponding N-substituted pyrazolines 7a–f and 8a–f respectively. Additionally, the regioselective cyclocondensation reaction of

  由咖啡因基醛3和取代的苯乙酮4a-f合成了一系列新的查耳酮5a -f。用水合肼处理化合物5a-f产生吡唑啉6a-f，随后与乙酸酐或甲酸反应，分别得到相应的N-取代吡唑啉7a-f和8a-f。此外，查尔酮5a–f与4,5-二氨基吡唑9的区域选择性环缩合反应提供了二氮杂衍生物10a–f。上述新化合物的合成是通过简单的方法进行的，该方法包括易于后处理和温和的反应条件。对于获得的化合物，评估了其对恶性疟原虫的体外抗疟活性。其中，当以20μg/ mL的浓度进行测试时，仅吡唑啉6a表现出显着的生长抑制率85.2±5.4％，而二氮杂10a-f显示出显着的生长抑制率，范围为80.3±13.5至94.2±0.2％。化合物5b，5e，7c和7f在20μg/ mL浓度下，对巴拿马利什曼原虫表现出显着的抑制活性，分别为88.3±1.5、82.6±2.2、82.8±1.7和87.6±0.5％。针对克氏锥虫的体外试验表明，吡唑啉6d在20μg/
• [EN] DYE COMPOSITION COMPRISING A CATIONIC O-ALKYL-SUBSTITUTED META-PHENYLENEDIAMINE DERIVATIVE<br/>[FR] COMPOSITION DE TEINTURE COMPRENANT UN DÉRIVÉ DE MÉTA-PHÉNYLÈNEDIAMINE CATIONIQUE À SUBSTITUTION ALKYLE O
  申请人：OREAL

  公开号：WO2014026952A1

  公开（公告）日：2014-02-20

  The invention relates to a meta-phenylenediamine compound of formula (I) below, the addition salts thereof with an acid and the solvates thereof: in which: R represents a hydrogen or halogen atom; a C1-C4 alkyl radical; a carboxyl radical or a (C1-C4) alkoxycarbonyl radical, R1 represents a linear C1-C10 alkyl radical substituted with a cationic radical, said alkyl radical being optionally interrupted with one or more oxygen atoms and/or with one or more NR6 groups, said cationic radical being optionally substituted with one or more radicals chosen from C1-C4 alkoxy or C1-C4 (hydroxy )alkyl; R6 represents a hydrogen atom or a linear or branched C1-C4 alkyl radical; An- represents an anion or a mixture of anions which are organic or inorganic and cosmetically acceptable.

  该发明涉及以下式（I）的一个甲苯二胺类化合物，以及其与酸的加合盐和溶剂化合物：其中：R代表氢或卤素原子；一个C1-C4烷基基团；一个羧基或（C1-C4）烷氧羰基基团，R1代表一个线性的C1-C10烷基基团，该基团被一个阳离子基团取代，所述烷基基团可以选择性地被一个或多个氧原子和/或一个或多个NR6基团中断，所述阳离子基团可以选择性地被一个或多个从C1-C4烷氧基或C1-C4（羟基）烷基中选择的基团取代；R6代表氢原子或线性或支链的C1-C4烷基基团；An-代表一个有机或无机且在化妆品中可接受的阴离子或阴离子混合物。
• Novel double para-phenylenediamines joined by a linker arm substituted with at least one group chosen from hydroxyl, alkoxy, and/or amino groups and method of dyeing keratinous fibers
  申请人：Sabelle Stéphane

  公开号：US20070011827A1

  公开（公告）日：2007-01-18

  Disclosed herein is a novel family of double para-phenylenediamines joined by a linker arm comprising at least one substituent chosen from hydroxyl, alkoxy, and/or amino substituents. Also disclosed herein is a dyeing composition comprising, in a medium suitable for dyeing, at least one para-phenylenediamine joined by a linker arm comprising at least one substituent chosen from hydroxyl, alkoxy, and/or amino substituents. Further disclosed herein is a method for dyeing keratin fibers comprising applying such a dyeing composition to the keratin fibers. A multi-compartment kit comprising at least one dyeing composition of the present disclosure and at least one oxidizing composition is also disclosed herein.

  本文揭示了一类新型的双对苯二胺家族，其由至少选择自羟基、烷氧基和/或氨基取代基的连接臂连接在一起。本文还揭示了一种染料组合物，其中在适合染色的介质中，至少有一种通过连接臂连接的对苯二胺，其连接臂包含至少选择自羟基、烷氧基和/或氨基取代基。此外，本文还揭示了一种染色角蛋白纤维的方法，包括将这种染料组合物应用于角蛋白纤维。本文还揭示了一种多室套装，其中至少包括本公告中的染料组合物和至少一种氧化剂组合物。
• NEW AMINOINDOLIZINES, DYEING COMPOSITION COMPRISING AT LEAST ONE AMINOINDOLIZINE, METHODS AND USES THEREOF
  申请人：VIDAL Laurent

  公开号：US20090235467A1

  公开（公告）日：2009-09-24

  A new class of chemical entities chosen from aminoindolizines of formula (I), acid addition salts thereof, and solvates thereof: their use for dyeing keratin fibers, including human keratin fibers such as the hair; dyeing compositions comprising such chemical entities; and to kits containing compositions comprising those chemical entities.

  从式(I)的氨基吲哚啉类化合物中选择的一类新化学实体，其酸加成盐和溶剂化物：它们用于染色角蛋白纤维，包括人类角蛋白纤维，如头发；包含这些化学实体的染料组合物；以及包含含有这些化学实体的组合物的工具包。
• [EN] CATIONIC PARA-PHENYLENEDIAMINES, COMPOSITION COMPRISING AT LEAST SUCH COMPOUNDS, IMPLEMENTATION PROCESS THEREFOR AND USE THEREOF<br/>[FR] PARAPHÉNYLÈNEDIAMINES CATIONIQUES, COMPOSITION COMPRENANT AU MOINS DE TELS COMPOSÉS, PROCÉDÉ DE MISE EN OEUVRE ET UTILISATION
  申请人：OREAL

  公开号：WO2013087934A1

  公开（公告）日：2013-06-20

  The present invention relates to particular cationic paraphenylenediamine compounds of formula (I) below and also to the use thereof for dyeing keratin fibres, in particular human keratin fibres such as the hair. The invention also relates to a dye composition comprising, in a suitable dyeing medium, one or more cationic para-phenylenediamines as defined previously. Finally, the invention relates to a dyeing device using the said composition.

  本发明涉及以下式（I）的特定阳离子对苯二胺化合物，以及其用于染色角蛋白纤维，特别是人类角蛋白纤维如头发的用途。该发明还涉及一种染料组合物，其中在适当的染料介质中包含一个或多个如前所定义的阳离子对苯二胺。最后，该发明涉及使用所述组合物的染色装置。