2,3-diphenyl-4-(phenylamino)quinoline | 70376-22-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,3-diphenyl-4-(phenylamino)quinoline
• 英文别名: (2,3-diphenyl-quinolin-4-yl)-phenyl-amine；(2,3-diphenyl-[4]quinolyl)-phenyl-amine；(2,3-Diphenyl-[4]chinolyl)-phenyl-amin；4-Phenylamino-2,3-diphenylchinolin；N,2,3-triphenylquinolin-4-amine
• CAS: 70376-22-6
• 化学式: C₂₇H₂₀N₂
• 分子量: 372.469
• InChiKey: LDRKADLZHKVMDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3-diphenyl-4-(phenylamino)quinoline 在 氢氧化钾 、 乙醇 作用下， 生成 2,3-diphenylquinolin-4(1H)-one
  参考文献：
  名称：

  Frontal lobe dysfunction in amyotrophic lateral sclerosis

  摘要：

  The aim of the present study was to investigate the involvement of frontal lobe dysfunction in amyotrophic lateral sclerosis (ALS) using ocular motor paradigms and neuropsychological testing. Fifty-one patients with ALS participated in the following ocular motor tasks: (1) a three-choice task and (2) a remembered saccade task. The patients underwent a clinical and neuropsychological evaluation. One-third of ALS patients presented with signs of frontal dysfunction, as determined by their high distractibility factors (DF) in the three-choice task and their performances in both the Wisconsin and Stroop tests. ALS patients exhibited longer latencies to eye movement than controls in the performance of the remembered saccade task, specifically in performance of both remembered and delayed saccades, but saccade accuracy was not impaired. Finally, performance indices of the ocular motor tasks, in particular the DF, was correlated only with the degree of dysarthria. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-510x(01)00683-9
• 作为产物：
  描述：

  二苯基乙酮 、 1,1-二苯基硫脲 生成 2,3-diphenyl-4-(phenylamino)quinoline
  参考文献：
  名称：

  Dziewonski; Moszew, Roczniki Chemii, 1934, vol. 14, p. 1123,1133

  摘要：

  DOI：

文献信息

• One-pot palladium-catalyzed C–I and C–H bond activation and subsequent Suzuki–Miyaura cross-coupling of 2-aryl-3-iodo-4-(phenylamino)quinolines with arylboronic acids
  作者：Malose J. Mphahlele、Mamasegare M. Mphahlele

  DOI：10.1016/j.tet.2011.04.040

  日期：2011.6

  The 2-aryl-3-iodo-4-(phenylamino)quinolines undergo one-pot palladium-mediated C–I and C–H bond activation and subsequent Suzuki–Miyaura cross-coupling with arylboronic acids under anhydrous conditions to afford mixture of 2,3-diaryl-4-(phenylamino)quinolines (minor) and 2-aryl-4-([(1,1′-biaryl)-2-yl]amino)quinoline derivatives (major). The 2,3-diaryl-4-(phenylamino)quinolines were isolated as major

  2-芳基-3-碘-4-（苯基氨基）喹啉经过一锅钯介导的C–I和C–H键活化，随后在无水条件下与芳基硼酸进行Suzuki–Miyaura交叉偶联，得到2的混合物，3-二芳基-4-（苯基氨基）喹啉（次要）和2-芳基-4-（[（（1,1'-联芳基-2-基）氨基]喹啉）衍生物（主要）。当以2 MK 2 CO 3为碱时，分离出2,3-二芳基-4-（苯基氨基）喹啉为主要产物。提出了一种可能的机制，该机制涉及六元的palladacycle中间体，用于形成观察到的产物混合物。结合光谱学和X射线晶体学技术对制备的化合物进行表征。
• Certain 4-Hydroxyquinolines from Aniline and β-Ketonitriles. Cyclizations of Nitriles through Amides by Means of Polyphosphoric Acid
  作者：Charles R. Hauser、James G. Murray

  DOI：10.1021/ja01615a055

  日期：1955.5
• Dziewonski et al., Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1934, vol. <A>, p. 190,194
  作者：Dziewonski et al.

  DOI：——

  日期：——
• CAPUANO L.; URHAHN G.; WILLMES A., CHEM. BER., 1979, 112, NO 3, 1012-1022
  作者：CAPUANO L.、 URHAHN G.、 WILLMES A.

  DOI：——

  日期：——