2,5-bis(3-quinolylhydroxymethyl)thiophene | 467426-05-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,5-bis(3-quinolylhydroxymethyl)thiophene
• 英文别名: [5-[Hydroxy(quinolin-3-yl)methyl]thiophen-2-yl]-quinolin-3-ylmethanol
• CAS: 467426-05-7
• 化学式: C₂₄H₁₈N₂O₂S
• 分子量: 398.485
• InChiKey: DOTVMMJBUXZMHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  94.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Thiaporphyrin, selenaporphyrin, and carotenoid porphyrin compounds as c-myc and telomerase inhibitors
  申请人：——

  公开号：US20030105130A1

  公开（公告）日：2003-06-05

  The present invention has identified thiaprophyrin, selenaporphyrin, and carotenoid porphyrin compounds that bind the G-quadruplex formed by the folding of single-stranded human telomeric DNA. These compounds have been shown to be effective telomerase and c-myc inhibitors and are contemplated to be useful in developing cancer treatments.

  本发明已经确定了硫代卟啉、硒代卟啉和类胡萝卜素卟啉化合物，这些化合物与由单链人类端粒DNA折叠形成的G-四链体结合。这些化合物已被证明是有效的端粒酶和c-myc抑制剂，并被考虑用于开发癌症治疗。
• [EN] THIAPORPHYRIN, SELENAPORPHYRIN, AND CAROTENOID PORPHYRIN COMPOUNDS AS C-MYC AND TELOMERASE INHIBITORS<br/>[FR] COMPOSES DE THIAPORPHYRINE, DE SELENAPORPHYRINE ET DE PORPHYRINE CAROTENOIDE UTILISES COMME INHIBITEURS DE C-MYC ET DE LA TELOMERASE
  申请人：UNIV TEXAS

  公开号：WO2002078695A1

  公开（公告）日：2002-10-10

  The present invention has identified thiaporphyrin, selenaporphyrin, and carotenoid porphyrin compounds that bind the G-quadruplex formed by the folding of single-stranded human telomeric DNA. These compounds have been shown to be effective telomerase and c-myc inhibitors and are contemplated to be useful in developing cancer treatments.