(E)-1-iodo-4-(tert-butyldimethylsiloxy)-6-phenyl-5,5-trimethylene-1-hexene | 433220-13-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1-iodo-4-(tert-butyldimethylsiloxy)-6-phenyl-5,5-trimethylene-1-hexene
• CAS: 433220-13-4
• 化学式: C₂₁H₃₃IOSi
• 分子量: 456.482
• InChiKey: BGDFRBKDQBVNSF-CXUHLZMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.13
• 重原子数：
  24.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (E)-1-iodo-4-(tert-butyldimethylsiloxy)-6-phenyl-5,5-trimethylene-1-hexene 在 porcine liver esterase 、 ammonium sulfate 、 氢氟酸 、 叔丁基锂 、 lithium,azanidylidenemethylidenecopper,2H-thiophen-2-ide 作用下， 以 四氢呋喃 、 phosphate buffer 、 乙醚 、 乙醇 、 乙腈 、 正戊烷 为溶剂， 反应 8.5h， 生成
  参考文献：
  名称：

  Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives

  摘要：

  Design and synthesis of an EP2-receptor selective agonist began with the chemical modification of alpha- and omega-chains of butaprost 1a, which exhibits an affinity for the IP-receptor. Two series of prostaglandin (PG) analogues with a 16-hydroxy-17,17-trimethylene moiety as an omega-chain were identified. Among those tested, 4a,b,e,f,h and 6a,b,e,f,h were found to be highly selective EP2-receptor agonists. Structure activity relationships are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00369-8
• 作为产物：
  描述：

  在 2,6-二甲基吡啶 、 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 二氯甲烷 为溶剂， 反应 2.34h， 生成 (E)-1-iodo-4-(tert-butyldimethylsiloxy)-6-phenyl-5,5-trimethylene-1-hexene
  参考文献：
  名称：

  Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives

  摘要：

  Design and synthesis of an EP2-receptor selective agonist began with the chemical modification of alpha- and omega-chains of butaprost 1a, which exhibits an affinity for the IP-receptor. Two series of prostaglandin (PG) analogues with a 16-hydroxy-17,17-trimethylene moiety as an omega-chain were identified. Among those tested, 4a,b,e,f,h and 6a,b,e,f,h were found to be highly selective EP2-receptor agonists. Structure activity relationships are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00369-8